新生儿体外支持技术的进展：体外膜氧合和人工胎盘的作用。

Advances in neonatal extracorporeal support: the role of extracorporeal membrane oxygenation and the artificial placenta.

机构信息

Section of Pediatric Surgery, C.S. Mott Children's Hospital, University of Michigan Health System, B560 MSRBII, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.

出版信息

Clin Perinatol. 2012 Jun;39(2):311-29. doi: 10.1016/j.clp.2012.04.006.

DOI:10.1016/j.clp.2012.04.006

PMID:22682382

Abstract

This review addresses the history and evolution of neonatal extracorporeal membrane oxygenation (ECMO), with a discussion of the indications, contraindications, modalities, outcomes, and impact of ECMO. Controversies surrounding novel uses of ECMO in neonates, namely ECMO for premature infants and ex utero intrapartum therapy with transition to ECMO, are discussed. The development of an extracorporeal artificial placenta for support of premature infants is presented, including the rationale, research, and challenges. ECMO has had a dramatic effect on the care of critically ill neonates over the past 4 decades, and there is great potential to expand these benefits in the future.

摘要

这篇综述探讨了新生儿体外膜肺氧合（ECMO）的历史和演变，讨论了 ECMO 的适应证、禁忌证、方式、结果和影响。还讨论了 ECMO 在新生儿中的新用途，即早产儿 ECMO 和经子宫内分娩至 ECMO 的治疗，以及为早产儿提供支持的体外人工胎盘的发展，包括其基本原理、研究和挑战。在过去的 40 年中，ECMO 对危重新生儿的治疗产生了巨大影响，未来还有很大的潜力扩大这些益处。