Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnett Avenue, Cincinnati, OH 45229, USA.
Endocrinol Metab Clin North Am. 2012 Jun;41(2):265-82, v. doi: 10.1016/j.ecl.2012.04.010.
Specific lesions of the growth hormone (GH)/insulin-like growth factor (IGF) axis have been identified in humans, each of which has distinctive auxologic and biochemical features. Measures of circulating IGF-I are useful in diagnosing growth disorders in childhood and in evaluating response to GH therapy. Recombinant human IGF-I is an effective treatment of severe primary IGF deficiency, which is typical of patients with GH receptor defects (Laron syndrome). Such treatment has been limited to a few severely affected patients. Future studies will provide new insight into IGF-I as treatment and into the nature of growth disorders that involve the IGF axis.
生长激素（GH）/胰岛素样生长因子（IGF）轴的特定病变已在人类中被确定，其中每种病变都具有独特的生长和生化特征。循环 IGF-I 的测量值可用于诊断儿童生长障碍，并评估对 GH 治疗的反应。重组人生长激素（rhGH）是严重原发性 IGF 缺乏症的有效治疗方法，这种疾病是 GH 受体缺陷（拉隆综合征）患者的典型表现。这种治疗方法仅限于少数严重受影响的患者。未来的研究将为 IGF-I 的治疗以及涉及 IGF 轴的生长障碍的性质提供新的见解。
