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损伤控制性手术对腹部大血管创伤的影响。

Effect of damage control surgery on major abdominal vascular trauma.

机构信息

University of Colorado Denver, Denver, Colorado, USA.

出版信息

J Surg Res. 2012 Oct;177(2):320-5. doi: 10.1016/j.jss.2012.05.020. Epub 2012 May 24.

Abstract

BACKGROUND

In 1982, we reported our experience with abdominal vascular trauma, highlighting the critical role of hypothermia, acidosis, and coagulopathy. Damage control surgery was subsequently introduced to address this "lethal triad." The purpose of the present study was to evaluate the outcomes from our most recent 6-year experience compared with a cohort from 30 years ago.

METHODS

Patients with major abdominal vascular injuries were examined, and the most recent 6-year period was compared with archived data from a similar 6-year period three decades ago.

RESULTS

The number of patients with major abdominal vascular injuries decreased from 123 patients in 1975 to 1980 to 64 patients in 2004 to 2009. The mean initial pH decreased from 7.21 to 6.96 (1975 to 1980 versus 2004 to 2009) for patients with overt coagulopathy. Despite increasingly protracted acidosis, mortality attributable to refractory coagulopathy decreased from 46% to 19% (1975 to 1980 versus 2004 to 2009, chi-square = 4.36, P = 0.04). No significant difference was found in mortality from exsanguinating injuries (43% versus 62%, 1975 to 1980 versus 2004 to 2009, chi-square = 1.96, P = 0.16). The prehospital transport times were unchanged (22 versus 20 min, 1975 to 1980 versus 2004 to 2009). Despite the administration of additional clotting factors and the advent of damage control surgery, the overall mortality remained largely unchanged (37% versus 33%, 1975 to 1980 versus 2004 to 2009, chi-square = 0.385, P = 0.53).

CONCLUSIONS

The adoption of damage control surgery, including the implementation of a massive transfusion protocol, was associated with a reduction in mortality for abdominal vascular injuries due to coagulopathy; however, patients have continued to die of exsanguination.

摘要

背景

1982 年,我们报告了腹部血管创伤的经验,强调了低温、酸中毒和凝血障碍的关键作用。随后引入了损伤控制手术来解决这一“致死三联征”。本研究的目的是评估我们最近 6 年的结果,并与 30 年前的一个队列进行比较。

方法

检查了患有严重腹部血管损伤的患者,并将最近的 6 年期间与 30 年前类似的 6 年期间的存档数据进行了比较。

结果

患有严重腹部血管损伤的患者人数从 1975 年至 1980 年的 123 例减少至 2004 年至 2009 年的 64 例。明显凝血障碍患者的初始 pH 值从 7.21 降至 6.96(1975 年至 1980 年与 2004 年至 2009 年)。尽管酸中毒持续时间延长,但归因于难治性凝血障碍的死亡率从 46%降至 19%(1975 年至 1980 年与 2004 年至 2009 年,卡方=4.36,P=0.04)。失血性损伤的死亡率没有显著差异(43%比 62%,1975 年至 1980 年与 2004 年至 2009 年,卡方=1.96,P=0.16)。院前转运时间保持不变(22 分钟比 20 分钟,1975 年至 1980 年与 2004 年至 2009 年)。尽管输注了更多的凝血因子并采用了损伤控制手术,但总体死亡率仍基本保持不变(37%比 33%,1975 年至 1980 年与 2004 年至 2009 年,卡方=0.385,P=0.53)。

结论

采用损伤控制手术,包括实施大量输血方案,与凝血障碍引起的腹部血管损伤的死亡率降低有关;然而,患者仍死于失血性休克。

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