Department of Neurology, University Hospital, Zagreb, Croatia.
Epilepsy Behav. 2012 Aug;24(4):426-9. doi: 10.1016/j.yebeh.2012.05.005. Epub 2012 Jun 8.
The objective of this study was to determine prevalence and predictive risk factors of suicidality in a large sample of epilepsy outpatients. We prospectively examined 193 consecutive adult epilepsy outpatients for depression, including suicidal ideation. Demographic and epilepsy factors, medication toxicity and health-related quality of life were also evaluated. The prevalence of suicidal ideation within the past two weeks was 11.9%. Although medication toxicity, health-related quality of life and BDI scores were each associated with suicidal ideation in the bivariate analyses, only the BDI remained significant in the logistic regression analysis. About one-fourth of the subjects with suicidal ideation had no significant symptoms of depression. Recent thoughts of suicide are a common occurrence in the outpatient epilepsy clinic setting, but these are not predicted by gender, age, seizure factors, medication toxicity or self-perceived quality of life. Although depression is associated with suicidal ideation, about one-fourth of the suicidal subjects were euthymic or only mildly depressed.
本研究旨在确定大量癫痫门诊患者自杀倾向的患病率和预测风险因素。我们前瞻性地检查了 193 名连续的成年癫痫门诊患者的抑郁情况，包括自杀意念。还评估了人口统计学和癫痫因素、药物毒性和与健康相关的生活质量。过去两周内自杀意念的患病率为 11.9%。虽然药物毒性、与健康相关的生活质量和 BDI 评分在双变量分析中均与自杀意念相关，但只有 BDI 在逻辑回归分析中仍然具有显著性。大约四分之一有自杀意念的患者没有明显的抑郁症状。在癫痫门诊环境中，最近有自杀念头是很常见的，但这些因素与性别、年龄、发作因素、药物毒性或自我感知的生活质量无关。虽然抑郁与自杀意念有关，但大约四分之一的有自杀意念的患者情绪稳定或仅有轻度抑郁。
