在十字路口：EGFR 和 PTHrP 信号在癌症引起的骨骼疾病中的作用。
At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone.
机构信息
Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA.
出版信息
Odontology. 2012 Jul;100(2):109-29. doi: 10.1007/s10266-012-0070-5. Epub 2012 Jun 10.
Abstract
The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.
摘要
表皮生长因子受体是一个成熟的癌症治疗靶点，因为它能刺激增殖、运动和抵抗细胞凋亡。最近，该受体在转移瘤生长中的作用也被确定。与发育过程相似，转移扩散需要上皮来源的肿瘤细胞和微环境的间质衍生物之间的信号相互作用。这就需要重新激活包括高钙血症因子甲状旁腺激素相关蛋白在内的发育信号分子。这篇综述涵盖了产生骨转移的癌症中表皮生长因子受体信号的变化、甲状旁腺激素相关蛋白的调节以及这两个分子驱动癌症引起的骨骼疾病的证据。
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