Yamanaka H
Kanebo Institute for Cancer Research, Osaka, Japan.
Int J Dev Biol. 1990 Sep;34(3):385-90.
Cellular patterns of the oviduct epithelium from the Japanese quail were examined during maturation. The epithelium of a juvenile bird showed a jigsaw puzzle pattern consisting of a single, undifferentiated cell type. At the start of maturation, cells were rearranged into a pattern in which the length of boundaries between goblet type gland (G-) cells and ciliated (C-) cells (G-C boundaries) were maximized. At this stage, the surface area of G-cells was much smaller, but G-cells are more than 2 times more numerous than C-cells. Cells than gradually rearranged themselves into the checkerboard pattern through an increase in the proportion of C-cells and enlargement of the G-cells. At all times of maturation, the length of G-C boundaries was maximized. These observations strongly support the theory that the cellular pattern of the quail oviduct epithelium is spontaneously constructed by maximizing the length of boundaries between two different types of cells owing to the fact that theirs is the greatest adhesion capacity (Yamanaka and Honda, 1990).
在成熟过程中对日本鹌鹑输卵管上皮的细胞模式进行了检查。幼鸟的上皮呈现出由单一未分化细胞类型组成的拼图模式。在成熟开始时，细胞重新排列成一种模式，其中杯状腺（G-）细胞和纤毛（C-）细胞之间边界（G-C边界）的长度最大化。在这个阶段，G-细胞的表面积要小得多，但G-细胞的数量比C-细胞多两倍以上。然后细胞通过C-细胞比例的增加和G-细胞的增大逐渐重新排列成棋盘模式。在成熟的所有阶段，G-C边界的长度都是最大化的。这些观察结果有力地支持了这样一种理论，即鹌鹑输卵管上皮的细胞模式是由于两种不同类型细胞之间边界长度最大化而自发构建的，因为它们具有最大的粘附能力（Yamanaka和Honda，1990）。
