San Francisco Department of Public Health Laboratory, San Francisco, California 94102, USA.
Microb Drug Resist. 2012 Oct;18(5):510-7. doi: 10.1089/mdr.2011.0229. Epub 2012 Jun 11.
Urogenital Neisseria gonorrhoeae isolates (266) collected in San Francisco, CA, in 2009 were analyzed for antimicrobial susceptibility and were subsequently genotyped by N. gonorrhoeae multiantigen sequence typing (NG-MAST). Isolates of identical or closely related sequence types were found to possess highly similar phenotypes with regard to drug susceptibility. Isolates containing decreased susceptibility to oral cephalosporins were detected in 2009 and were found to contain the mosaic penA allele (XXXIV) found previously to be associated with decreased susceptibility to cephalosporins. A better understanding of the relationships between phenotypic and genotypic markers for antimicrobial resistance may be helpful to the development of effective surveillance systems for drug-resistant N. gonorrhoeae.
2009 年，在美国加利福尼亚州旧金山收集的泌尿生殖道淋病奈瑟菌分离株（266 株）进行了抗菌药物敏感性分析，并随后通过淋病奈瑟菌多抗原序列分型（NG-MAST）进行了基因分型。具有相同或密切相关序列型的分离株在药物敏感性方面表现出高度相似的表型。2009 年检测到对口服头孢菌素的敏感性降低的分离株，发现它们含有先前与头孢菌素敏感性降低相关的马赛克 penA 等位基因（XXXIV）。更好地了解抗菌药物耐药性的表型和基因型标记之间的关系，可能有助于开发针对耐药淋病奈瑟菌的有效监测系统。
