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自身免疫性多腺体综合征:空蝶鞍、卵巢早衰、桥本甲状腺炎伴甲状腺癌的不常见表现。

Autoimmune polyglandular syndrome: an unusual presentation with empty sella, premature ovarian failure, and Hashimoto's thyroiditis associated with thyroid cancer.

机构信息

Department of Neuroendocrinology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.

出版信息

Gynecol Endocrinol. 2012 Dec;28(12):999-1001. doi: 10.3109/09513590.2012.692222. Epub 2012 Jun 12.

DOI:10.3109/09513590.2012.692222
PMID:22686234
Abstract

Autoimmune polyglandular syndromes are rare disorders characterized by failure of several endocrine glands, as well as non-endocrine organs, associated with immune-mediated tissue destruction. We report a rare case of polyglandular syndrome type II in a patient who presented with premature ovarian failure, Hashimoto's thyroiditis and empty sella associated with a diagnosis of differentiated thyroid carcinoma. This case probably represents the first report on this tumor in a patient with polyglandular disorder.

摘要

自身免疫性多腺体综合征是一种罕见的疾病,其特征是多个内分泌腺体以及非内分泌器官的功能衰竭,与免疫介导的组织破坏有关。我们报告了一例罕见的 II 型多腺体综合征病例,该患者表现为卵巢早衰、桥本甲状腺炎和空蝶鞍,同时伴有分化型甲状腺癌的诊断。本例可能是首例报道的多腺体疾病患者伴发此种肿瘤的病例。

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Autoimmune polyglandular syndrome: an unusual presentation with empty sella, premature ovarian failure, and Hashimoto's thyroiditis associated with thyroid cancer.自身免疫性多腺体综合征:空蝶鞍、卵巢早衰、桥本甲状腺炎伴甲状腺癌的不常见表现。
Gynecol Endocrinol. 2012 Dec;28(12):999-1001. doi: 10.3109/09513590.2012.692222. Epub 2012 Jun 12.
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Premature ovarian failure associated with autoimmune polyglandular syndrome: pathophysiological mechanisms and future fertility.与自身免疫性多腺体综合征相关的卵巢早衰:病理生理机制与未来生育力
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Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction.卵巢早衰可能是多腺体自身免疫功能障碍的一个警示信号。
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引用本文的文献

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Case Report: A patient with an empty sella accompanied by rare thyrotoxicosis.病例报告:一名患有空蝶鞍并伴有罕见甲状腺毒症的患者。
Front Endocrinol (Lausanne). 2025 Aug 20;16:1516538. doi: 10.3389/fendo.2025.1516538. eCollection 2025.
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Polyglandular Autoimmune Syndrome III with Hypoglycemia and Association with Empty Sella and Hypopituitarism.伴有低血糖的自身免疫性多腺体综合征III及其与空蝶鞍和垂体功能减退的关联。
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