Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Ophthalmologica. 2012;228(3):159-66. doi: 10.1159/000337840. Epub 2012 Jun 8.
To study the effects of intravitreal injection (IVI) of expansile gas for early macular holes (EMH).
Prospective interventional case series. Twelve eyes of 12 patients with EMH (stage 2) underwent IVI of perfluoropropane 0.2 ml followed by 5 days' facedown positioning.
Six cases (50%) achieved vitreous-macula separation. Three cases (25%) had hole closure with vision improvement; one of them developed rhegmatogenous retinal detachment (RRD) and hole re-opening. Another case with persistent hole also developed RRD. Seven of the 9 cases without hole closure and the one where the hole re-opened had vitrectomy, all resulting in hole closure and vision improvement. Duration of symptoms had borderline significance for hole closure (p = 0.11) and subsequent visual improvement (p = 0.03).
With its low success rate, IVI of gas may not be a good option for EMH. Complications include retinal detachment. The procedure seems to not affect hole closure with subsequent vitrectomy.
研究眼内膨胀气体注射（IVI）对早期黄斑裂孔（EMH）的影响。
前瞻性干预性病例系列研究。12 例 EMH（2 期）患者的 12 只眼接受了 0.2ml 全氟丙烷的 IVI，随后进行了 5 天的面朝下体位。
6 例（50%）发生玻璃体-黄斑分离。3 例（25%）视力改善，孔闭合；其中 1 例发生孔源性视网膜脱离（RRD）和孔再开放。另 1 例持续存在孔的患者也发生了 RRD。9 例未闭合孔和 1 例孔再开放的患者行玻璃体切除术，均导致孔闭合和视力改善。症状持续时间对孔闭合（p=0.11）和随后的视力改善（p=0.03）有边界意义。
IVI 气体的成功率较低，可能不是 EMH 的理想选择。并发症包括视网膜脱离。该操作似乎不影响后续玻璃体切除术后的孔闭合。
