Ishino R, Yoshino H, Hirakawa Y, Noda K
Products Formulation Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1987-92. doi: 10.1248/cpb.38.1987.
To examine the influence of tabletting speed on compactibility and compressibility under high speed compression, two direct compressible powders, alpha-lactose monohydrate and microcrystalline cellulose of different particle size ranges were compressed using an instrumented rotary press with varying tabletting speed and compression force. The maximum applied force and total time during compression (contact time) were determined from a time-force profile, and the relation between these parameters and properties of compacts was examined. For all lactose tablets, the porosity and tensile strength of compacts were less affected by compression rate though they depended on the applied force. However, the properties of microcrystalline cellulose tablets were varied depending on the tabletting speed in addition to the applied force. In an attempt to quantitatively evaluate the effect of compression rate on the compactibility, an empirical equation was derived from the numerical analysis of the experimental data. The compactibility parameters deduced from the equation well elucidated the effect of tabletting speed on the properties of microcrystalline cellulose tablets and lactose tablets made of various particle size powders.
为了研究高速压片过程中压片速度对可压性和压缩性的影响，使用一台装有测量装置的旋转压片机，以不同的压片速度和压力对两种直接压片用粉末——不同粒径范围的α-一水乳糖和微晶纤维素进行压片。通过时间-压力曲线确定最大施加力和压缩过程中的总时间（接触时间），并研究这些参数与压片性质之间的关系。对于所有乳糖片剂，尽管压片孔隙率和抗张强度取决于施加的压力，但受压缩速率的影响较小。然而，除了施加的压力外，微晶纤维素片剂的性质还随压片速度而变化。为了定量评估压缩速率对可压性的影响，通过对实验数据的数值分析推导了一个经验方程。从该方程推导出的可压性参数很好地阐明了压片速度对由不同粒径粉末制成的微晶纤维素片剂和乳糖片剂性质的影响。
