Liu Y Y
Central Laboratory, Hunan College of TCM, Changsha.
Zhong Xi Yi Jie He Za Zhi. 1990 Nov;10(11):675-6, 645.
In this paper, the authors report the therapeutic effects of Ginseng-Aconitum-Bupleurum (GAB) injection on septic shock complicated with DIC induced by intravenous injection of live E. Coli in dogs. The experimental results indicated that the survival rate at 48 h after intravenous injection of live E. Coli was 30% in saline group, 80% in GAB, 90% in dexamethasone (Dex) group. The BPC, WBC, FG, AT-III, beta-GC, PHb were 82 +/- 28, 9.1 +/- 5.9, 1.85 +/- 0.41, 112 +/- 43, 0.37 +/- 0.17, 0.11 +/- 0.07 respectively for GAB, 70 +/- 37, 6.7 +/- 3.7, 1.55 +/- 0.36, 59 +/- 29, 0.91 +/- 0.28, 0.12 +/- 0.06 respectively for the saline group, 58 +/- 33, 6.3 +/- 2.9, 1.95 +/- 0.21, 103 +/- 43, 0.50 +/- 0.16, 0.13 +/- 0.06 respectively for Dex. The BPC, WBC, FG, AT-III levels of the GAB group were significantly higher than those in saline group and were not significantly difference from the Dex group. The beta-GC and PHb levels of the GAB group were significantly reductive than the saline group and were not significantly different from the Dex group. The results showed that the survival rate was higher, the DIC was inhibited and normal biomembranes were maintained in the GAB group.
在本文中，作者报告了参附柴注射液对犬静脉注射活大肠杆菌所致脓毒性休克并发弥散性血管内凝血（DIC）的治疗效果。实验结果表明，静脉注射活大肠杆菌后48小时，生理盐水组的存活率为30%，参附柴组为80%，地塞米松（Dex）组为90%。参附柴组的血小板计数（BPC）、白细胞计数（WBC）、纤维蛋白原（FG）、抗凝血酶Ⅲ（AT-Ⅲ）、β-球蛋白（β-GC）、血浆高铁血红蛋白（PHb）分别为82±28、9.1±5.9、1.85±0.41、112±43、0.37±0.17、0.11±0.07；生理盐水组分别为70±37、6.7±3.7、1.55±0.36、59±29、0.91±0.28、0.12±0.06；地塞米松组分别为58±33、6.3±2.9、1.95±0.21、103±43、0.50±0.16、0.13±0.06。参附柴组的BPC、WBC、FG、AT-Ⅲ水平显著高于生理盐水组，与地塞米松组无显著差异。参附柴组的β-GC和PHb水平显著低于生理盐水组，与地塞米松组无显著差异。结果显示，参附柴组存活率更高，DIC得到抑制，生物膜保持正常。
