Neuropsychiatric Epidemiology Research Unit, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.
Aust N Z J Psychiatry. 2012 Aug;46(8):762-73. doi: 10.1177/0004867412450471. Epub 2012 Jun 11.
Most people diagnosed with a psychotic disorder will be prescribed psychotropic medication. The second Australian national survey of psychosis provided a unique opportunity to examine the pharmacological treatment of psychotic disorders from the perspective of the consumer. The aim of this paper is to report on medication use, adherence and perceived efficacy, and to describe side effect profiles.
Data on self-reported medication use in the 4 weeks prior to interview, including type, duration, adherence, side effects and helpfulness was collected from participants interviewed in the course of the second Australian national survey of psychosis.
The majority (91.6%) of participants were using psychotropic medication: 89.0% of people aged 18-34 years and 93.5% of people aged 35-64 years. The most commonly used class of medication was antipsychotic medication (81.6%). In addition, 37.4% were using antidepressants, 26.7% were using mood stabilisers and 17.8% were using anxiolytics/hypnotics. Polypharmacy was common with almost two-thirds (63.4%) using more than one class of medication and over a quarter (28.1%) of people with schizophrenia using more than one antipsychotic. Many participants (84.4%) reported experiencing side effects. The side effect profile of people using atypical antipsychotics was on average better than that of people using typical antipsychotics. Most people (85.2%) felt their medication relieved their mental health symptoms and most (88.2%) medication was taken as prescribed.
Many people with a psychotic disorder are receiving antipsychotics, with a substantial proportion also taking antidepressants, mood stabilisers and anxiolytics/hypnotics. Medication use differs by age group, diagnostic group and course of illness. Many people using antipsychotics describe significant impairment in their everyday life as a result of medication side effects. Users of typical antipsychotics reported more side effects and more impairment than people using atypical antipsychotics. Most of our participants were prescribed psychotropic medications, and most reported that they were taking them.
大多数被诊断患有精神病的患者会被开具精神类药物。第二次澳大利亚全国精神病学调查为从消费者角度检查精神病的药物治疗提供了一个独特的机会。本文旨在报告药物使用、依从性和感知疗效，并描述副作用概况。
从第二次澳大利亚全国精神病学调查中接受访谈的参与者收集了在访谈前 4 周内自我报告的药物使用情况，包括药物类型、持续时间、依从性、副作用和有效性。
大多数参与者（91.6%）正在使用精神类药物：18-34 岁的人群中有 89.0%，35-64 岁的人群中有 93.5%。使用最广泛的药物类别是抗精神病药物（81.6%）。此外，37.4%的人在使用抗抑郁药，26.7%的人在使用情绪稳定剂，17.8%的人在使用抗焦虑药/催眠药。联合用药很常见，近三分之二（63.4%）的人使用不止一种药物类别，超过四分之一（28.1%）的精神分裂症患者使用不止一种抗精神病药物。许多参与者（84.4%）报告有副作用。使用非典型抗精神病药物的人的副作用概况平均好于使用典型抗精神病药物的人。大多数人（85.2%）认为他们的药物缓解了他们的心理健康症状，大多数人（88.2%）按规定服药。
许多精神病患者正在接受抗精神病药物治疗，其中相当一部分人还同时服用抗抑郁药、情绪稳定剂和抗焦虑药/催眠药。药物使用因年龄组、诊断组和疾病过程而异。许多使用抗精神病药物的人描述说，由于药物副作用，他们的日常生活受到了严重影响。使用典型抗精神病药物的人比使用非典型抗精神病药物的人报告更多的副作用和更多的损伤。我们的大多数参与者都被开了精神类药物，大多数人报告说他们在服用。
