Xi Shaoyan, Zhang Yu, Lin Suxia, Liang Jianzhong, Zeng Jing, Wu Qiuliang
Sun Yat-Sen University Cancer Center, Guangzhou, China.
Int J Surg Pathol. 2012 Dec;20(6):600-5. doi: 10.1177/1066896912449043. Epub 2012 Jun 10.
Most meningiomas are benign and correspond to World Health Organization grade I, whereas chordoid meningioma is a rare subtype, which is regarded as grade II. This report presents 1 case of intraparenchymal chordoid meningioma. The intraparenchymal chordoid meningioma consisted predominantly of tissue that was histologically similar to chordoma, featuring cords or trabeculae of eosinophilic and often vacuolated cells in an abundant mucoid matrix background. Tumor cells were diffusing positive for epithelial membrane antigen and vimentin, and focusing positively for progesterone receptor, but showed lack of immunoreactivity with cytokeratin, S-100, and glial fibrillary acidic protein. Follow-up at 8 months showed no recurrence. Reports about chordoid meningioma are not uncommon, but reports on intraparenchymal lesion are rare. Besides, the result of magnetic resonance imaging in the present case suggested that intraparenchymal chordoid meningioma was a metastasis tumor. This report reminds of the importance of differential diagnosis in the case of intraparenchymal lesion.
大多数脑膜瘤是良性的，属于世界卫生组织一级，而脊索样脑膜瘤是一种罕见的亚型，被视为二级。本报告呈现了1例脑实质内脊索样脑膜瘤病例。脑实质内脊索样脑膜瘤主要由组织构成，这些组织在组织学上与脊索瘤相似，在丰富的黏液样基质背景中可见嗜酸性且常呈空泡状的细胞条索或小梁。肿瘤细胞上皮膜抗原和波形蛋白弥漫性阳性，孕激素受体局灶性阳性，但对细胞角蛋白、S-100和胶质纤维酸性蛋白无免疫反应性。8个月的随访显示无复发。关于脊索样脑膜瘤的报道并不少见，但关于脑实质内病变的报道却很罕见。此外，本例的磁共振成像结果提示脑实质内脊索样脑膜瘤是转移瘤。本报告提醒了在脑实质内病变情况下进行鉴别诊断的重要性。
