五词测验评估记忆门诊中老年患者情景记忆及痴呆的有效性。

Validity of the five-word test for the evaluation of verbal episodic memory and dementia in a memory clinic setting.

机构信息

Department of Neurology, CHU Mont-Godinne, Yvoir, Belgium.

出版信息

J Geriatr Psychiatry Neurol. 2012 Jun;25(2):78-84. doi: 10.1177/0891988712445088.

DOI:10.1177/0891988712445088

PMID:22689699

Abstract

BACKGROUND

The five-word test (FWT) uses semantic clues to optimize the encoding and retrieval of 5 items. Our objective was to assess the validity of the FWT as a measure of episodic memory when compared with the Free and Cued Selective Reminding Test (FCSRT), and its ability to distinguish participants with any dementia and especially Alzheimer disease (AD) from those with only subjective complaints.

METHODS

Two hundred participants with Mini-Mental State Examination (MMSE) >15 were prospectively evaluated. The sum of the immediate and delayed free recalls of the FWT is called the free recall score (FRS). The sum of the immediate free, immediate cued, delayed free, and delayed cued recalls is called the total recall score (TRS). A total weighted score (TWS) is calculated using this formula: (free recalls × 2) + cued recalls.

RESULTS

The correlation between FRS and the free recall scores of the FCSRT and between TRS and the total recall scores of the FCSRT was significant (r (s) ranges from .74-.84, P < .001). Area under the receiver--operating characteristic (ROC) curves of the MMSE, FRS, TRS, and TWS were not statistically different. A TWS at a cutoff value ≤15 could discriminate any dementia from subjective complaints with a sensitivity of 75% and a specificity of 95.9% or AD from subjective complaints with a sensitivity of 90.2% and a specificity of 95.9%.

CONCLUSION

The FWT is a valid test of verbal episodic memory. It is useful to discriminate dementia especially AD from isolated subjective complaints.

摘要

背景

五字测试（FWT）使用语义线索来优化 5 项内容的编码和检索。我们的目的是评估 FWT 作为一种衡量情景记忆的有效性，与自由和线索选择性回忆测试（FCSRT）相比，以及它区分有任何痴呆症，特别是阿尔茨海默病（AD）患者和仅有主观抱怨的参与者的能力。

方法

200 名简易精神状态检查（MMSE）>15 的参与者前瞻性评估。FWT 的即时和延迟自由回忆的总和称为自由回忆得分（FRS）。即时自由、即时线索、延迟自由和延迟线索回忆的总和称为总回忆得分（TRS）。使用以下公式计算总加权得分（TWS）：（自由回忆×2）+线索回忆。

结果

FRS 与 FCSRT 的自由回忆得分之间以及 TRS 与 FCSRT 的总回忆得分之间的相关性具有统计学意义（r（s）范围从.74-.84，P <.001）。MMSE、FRS、TRS 和 TWS 的受试者工作特征（ROC）曲线下面积没有统计学差异。TWS 的截断值≤15 可将任何痴呆症与主观抱怨区分开来，其敏感性为 75%，特异性为 95.9%，或将 AD 与主观抱怨区分开来，其敏感性为 90.2%，特异性为 95.9%。