治疗特应性皮炎：神经酰胺透明质酸保湿泡沫的安全性、疗效和患者可接受性。
Treating atopic dermatitis: safety, efficacy, and patient acceptability of a ceramide hyaluronic acid emollient foam.
机构信息
Department of Dermatology, University of Texas Health Science Center, Houston, TX, USA.
出版信息
Clin Cosmet Investig Dermatol. 2012;5:39-42. doi: 10.2147/CCID.S23269. Epub 2012 May 7.
Abstract
Advances in current understanding of the pathophysiology of atopic dermatitis have led to improved targeting of the structural deficiencies in atopic skin. Ceramide deficiency appears to be one of the major alterations in atopic dermatitis and the replenishment of this epidermal component through topically applied ceramide based emollients appears to be safe, well tolerated, and effective. Recently a ceramide hyaluronic acid foam has become commercially available and increasing evidence supports its safety and efficacy in patients who suffer from atopic dermatitis.
摘要
目前对特应性皮炎病理生理学的认识进展使得靶向治疗特应性皮肤的结构缺陷成为可能。 神经酰胺缺乏似乎是特应性皮炎的主要改变之一，通过局部应用神经酰胺类保湿剂来补充这种表皮成分似乎是安全、耐受良好且有效的。 最近，一种神经酰胺透明质酸泡沫已上市，越来越多的证据支持其在特应性皮炎患者中的安全性和有效性。
相似文献
1
Treating atopic dermatitis: safety, efficacy, and patient acceptability of a ceramide hyaluronic acid emollient foam.治疗特应性皮炎：神经酰胺透明质酸保湿泡沫的安全性、疗效和患者可接受性。
Clin Cosmet Investig Dermatol. 2012;5:39-42. doi: 10.2147/CCID.S23269. Epub 2012 May 7.
2
Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema.含乳木果油提取物脂质复合物的乳膏和洁面产品与一款用于湿疹的神经酰胺产品相比的患者可接受性、疗效及皮肤生物生理学特性
Hong Kong Med J. 2015 Oct;21(5):417-25. doi: 10.12809/hkmj144472. Epub 2015 Aug 28.
3
A clinical evaluation of the comparable efficacy of hyaluronic acid-based foam and ceramide-containing emulsion cream in the treatment of mild-to-moderate atopic dermatitis.一项临床评价比较了透明质酸泡沫剂和含神经酰胺乳液霜治疗轻中度特应性皮炎的等效疗效。
J Cosmet Dermatol. 2011 Sep;10(3):185-8. doi: 10.1111/j.1473-2165.2011.00568.x.
4
5
Emollient Acceptability in Childhood Atopic Dermatitis: Not All Emollients are Equal.儿童特应性皮炎中润肤剂的可接受性：并非所有润肤剂都一样。
Curr Pediatr Rev. 2018;14(2):117-122. doi: 10.2174/1573396313666170605080034.
6
Testing an Ectoin Containing Emollient for Atopic Dermatitis.测试一种含依克多因的润肤剂用于特应性皮炎的效果。
Curr Pediatr Rev. 2019;15(3):191-195. doi: 10.2174/1573396315666190415144244.
7
Testing the Actions of a Multi-action Emollient: Patient's Acceptability Determines Product Efficacy.测试一款多效润肤剂的作用：患者的接受度决定产品疗效。
Curr Pediatr Rev. 2018;14(2):110-116. doi: 10.2174/1573396313666171117114005.
8
[Optimization of emollient formulation for treating atopic dermatitis by skin physiological index testing].[通过皮肤生理指标测试优化治疗特应性皮炎的润肤剂配方]
Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):967-974. doi: 10.3969/j.issn.1673-4254.2017.07.21.
9
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity.神经酰胺主导的屏障修复脂质可缓解儿童特应性皮炎：屏障功能的变化为疾病活动提供了一个敏感指标。
J Am Acad Dermatol. 2002 Aug;47(2):198-208. doi: 10.1067/mjd.2002.124617.
10
Reevaluation of the non-lesional dry skin in atopic dermatitis by acute barrier disruption: an abnormal permeability barrier homeostasis with defective processing to generate ceramide.通过急性屏障破坏对特应性皮炎中非皮损性干性皮肤的重新评估：一种具有生成神经酰胺加工缺陷的异常渗透屏障稳态。
Arch Dermatol Res. 2014 Jul;306(5):427-40. doi: 10.1007/s00403-013-1430-x. Epub 2013 Nov 23.
引用本文的文献
1
Development of an Emulgel for the Effective Treatment of Atopic Dermatitis: Biocompatibility and Clinical Investigation.一种用于有效治疗特应性皮炎的乳胶凝胶的研发：生物相容性与临床研究。
Gels. 2024 May 27;10(6):370. doi: 10.3390/gels10060370.
2
A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial.一项针对中重度特应性皮炎成人患者的随机试验表明，每天使用富含神经酰胺的保湿霜和清洁剂可恢复皮肤的通透性屏障。
Dermatol Ther. 2021 Jul;34(4):e14970. doi: 10.1111/dth.14970. Epub 2021 May 24.
3
Hyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini Review.靶向炎症性皮肤病的透明质酸介导药物递送系统：一篇综述
Front Pharmacol. 2020 Jul 24;11:1105. doi: 10.3389/fphar.2020.01105. eCollection 2020.
4
Unsaturated fatty acid-enriched extract from Hippophae rhamnoides seed reduces skin dryness through up-regulating aquaporins 3 and hyaluronan synthetases 2 expressions.富含不饱和脂肪酸的沙棘籽油提取物通过上调水通道蛋白 3 和透明质酸合酶 2 的表达来减少皮肤干燥。
J Cosmet Dermatol. 2021 Jan;20(1):321-329. doi: 10.1111/jocd.13482. Epub 2020 Jul 8.
5
Topical treatment with SPHINGOLIPIDS and GLYCOSAMINOGLYCANS for canine atopic dermatitis.针对犬特应性皮炎的鞘脂类和糖胺聚糖的局部治疗。
BMC Vet Res. 2020 Mar 20;16(1):92. doi: 10.1186/s12917-020-02306-6.
本文引用的文献
1
2
Ceramide modulates HERG potassium channel gating by translocation into lipid rafts.神经酰胺通过转位进入脂筏调节 HERG 钾通道门控。
Am J Physiol Cell Physiol. 2010 Jul;299(1):C74-86. doi: 10.1152/ajpcell.00462.2009. Epub 2010 Apr 7.
3
Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema.特应性皮炎患者的角质层脂质、皮肤屏障功能和丝聚合蛋白突变。
Allergy. 2010 Jul;65(7):911-8. doi: 10.1111/j.1398-9995.2010.02326.x. Epub 2010 Feb 4.
4
Estimating the impact on the food chain of changing bovine spongiform encephalopathy (BSE) control measures: the BSE control model.评估改变牛海绵状脑病（BSE）控制措施对食物链的影响：BSE 控制模型。
Prev Vet Med. 2010 Feb 1;93(2-3):170-82. doi: 10.1016/j.prevetmed.2009.09.018.
5
The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties.含有 20%甘油的乳膏及其赋形剂对皮肤屏障特性的影响。
Int J Cosmet Sci. 2001 Apr;23(2):115-9. doi: 10.1046/j.1467-2494.2001.00060.x.
6
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.儿童中的丝聚合蛋白突变、特应性皮炎、花粉症和哮喘。
J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. doi: 10.1016/j.jaci.2008.02.014. Epub 2008 Apr 8.
7
On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.关于局部应用合成神经酰胺的效果：比较神经酰胺PC104、BIO391以及天然神经酰胺对角质形成细胞可能产生的毒性。
J Dermatol Sci. 2008 Jul;51(1):37-43. doi: 10.1016/j.jdermsci.2008.02.007. Epub 2008 Apr 8.
8
Noninvasive biophysical assessments of the efficacy of a moisturizing cosmetic cream base for patients with atopic dermatitis during different seasons.对特应性皮炎患者在不同季节使用保湿化妆品乳膏基质疗效的非侵入性生物物理评估。
Br J Dermatol. 2008 May;158(5):969-78. doi: 10.1111/j.1365-2133.2008.08478.x. Epub 2008 Mar 13.
9
The US FDA 'black box' warning for topical calcineurin inhibitors: an ongoing controversy.美国食品药品监督管理局（FDA）针对局部用钙调神经磷酸酶抑制剂的“黑框”警告：争议仍在继续。
Drug Saf. 2008;31(3):185-98. doi: 10.2165/00002018-200831030-00001.
10
A systematic review of the safety of topical therapies for atopic dermatitis.对特应性皮炎局部治疗安全性的系统评价。
Br J Dermatol. 2007 Feb;156(2):203-21. doi: 10.1111/j.1365-2133.2006.07538.x.
Zotero 插件