Zaki Faizah Mohd, Sridharan Radhika, Pei Tan Sook, Ibrahim Sharaf, Ping Tang Swee
Department of Radiology, Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia.
J Radiol Case Rep. 2012 Mar;6(3):1-8. doi: 10.3941/jrcr.v6i3.745. Epub 2012 Mar 1.
Neonatal onset multisystem inflammatory disease (NOMID) is a rare autoinflammatory disorder, which manifests early in infancy. We describe a case of a 10-year-old boy who has been unwell since infancy. He presented with urticarial rash, intermittent fever and hepatosplenomegaly followed by progressive arthropathy. His joint symptoms started at two years of age, which progressively involved multiple joints, resulting in bone and joint deformities. A series of joint radiographs demonstrated bizarre enlarging physeal mass with heterogenous calcification. Magnetic resonance imaging (MRI) of the involved right ankle and knee showed characteristic thickened and calcified physeal lesions, which enhanced post-gadolinium. This debilitating disease is also known to involve the central nervous system and eyes. This case report aims to highlight the conventional radiographic and magnetic resonance imaging (MRI) findings of this physeal abnormality in NOMID syndrome.
新生儿期起病的多系统炎症性疾病（NOMID）是一种罕见的自身炎症性疾病，在婴儿期早期发病。我们描述了一名自婴儿期起就身体不适的10岁男孩的病例。他出现荨麻疹样皮疹、间歇性发热和肝脾肿大，随后出现进行性关节病。他的关节症状始于两岁，逐渐累及多个关节，导致骨骼和关节畸形。一系列关节X线片显示出怪异的增大的干骺端肿块伴有不均匀钙化。受累的右踝和膝关节的磁共振成像（MRI）显示出特征性的增厚和钙化的干骺端病变，钆增强后有强化。这种使人衰弱的疾病还已知会累及中枢神经系统和眼睛。本病例报告旨在突出NOMID综合征中这种干骺端异常的传统X线和磁共振成像（MRI）表现。
