Cesca Eleonora, Garetto Giacomo, Frascella Emanuela, Cesaro Simone, Dall'igna Patrizia, Cecchetto Giovanni
Department of Pediatrics.
Pediatr Rep. 2012 Jan 2;4(1):e1. doi: 10.4081/pr.2012.e1. Epub 2011 Dec 27.
This study aimed to assess the feasibility and results of hyperbaric oxygen therapy (HOT) as supportive treatment of lesions of superficial soft tissues in children with oncological diseases. This was a retrospective analysis and review of all records of children observed at the Pediatric Hematology-Oncology Department of the University of Padova and treated adjuvantly with HOT. Between 1996 and 2010, 12 patients (5 males and 7 females, median age 7 years, range 0.5-16) underwent HOT. The effectiveness of HOT varied according to the lesion treated. Ten out of 12 patients were cured. Efficacy was most questionable in 2 patients with skin graft and flaps at risk. Compliance to therapy was close to 100%. In just one case, HOT was interrupted for the appearance of local skin metastases close to the site of primary tumor. HOT showed itself to be safe and effective in most patients even those immunocompromised or critically ill.
本研究旨在评估高压氧疗法（HOT）作为肿瘤性疾病患儿浅表软组织损伤辅助治疗的可行性及效果。这是一项对帕多瓦大学儿科血液肿瘤科观察并接受HOT辅助治疗的所有患儿记录的回顾性分析。1996年至2010年间，12例患者（5例男性，7例女性，中位年龄7岁，范围0.5 - 16岁）接受了HOT治疗。HOT的有效性因所治疗的损伤而异。12例患者中有10例治愈。对于2例有皮肤移植和皮瓣风险的患者，疗效最值得怀疑。治疗依从性接近100%。仅1例因原发肿瘤部位附近出现局部皮肤转移而中断HOT治疗。HOT在大多数患者中显示出安全有效，即使是免疫功能低下或危重症患者。
