Wu H W, Wen J X, Qu G R
Department of Internal Medicine, Second Affiliated Hospital Hunan Medical University, Zhangsha.
Zhonghua Nei Ke Za Zhi. 1990 Jun;29(6):357-9, 383.
Using the method of metabolic balance, we investigated the fluoride metabolism and its change during calcium-magnesium preparation treatment in 60 cases of endemic fluorosis. We found that in patients with fluorosis the intake of fluoride and the levels of urinary, fecal and serum fluoride were several times higher than those of normal controls (P less than 0.01), that the intestinal fluoride apparent absorption rate was 1.5 times higher than that of normal controls (P less than 0.01) and that at a given dietary level of fluoride, there existed a balance of fluoride metabolism. Fluoride intake was positively correlated with intestinal fluoride apparent absorption rate (r = 0.375, P less than 0.01). The combination of calcium and magnesium preparation with fluoride led to decrease of intestinal fluoride apparent rate (P less than 0.05) and increase of fecal fluoride output (P less than 0.05). It seems reasonable to treat fluorosis with calcium-magnesium preparation.
采用代谢平衡法，对60例地方性氟中毒患者在服用钙镁制剂治疗过程中的氟代谢及其变化进行了研究。我们发现，氟中毒患者的氟摄入量以及尿、粪和血清氟水平比正常对照组高出数倍（P<0.01），肠道氟表观吸收率比正常对照组高1.5倍（P<0.01），并且在给定的膳食氟水平下，存在氟代谢平衡。氟摄入量与肠道氟表观吸收率呈正相关（r = 0.375，P<0.01）。钙镁制剂与氟结合导致肠道氟表观吸收率降低（P<0.05）和粪氟排出量增加（P<0.05）。用钙镁制剂治疗氟中毒似乎是合理的。
