[Intrahepatic IgA and secretory component distribution and the mechanism of hyperSigAnemia].

Using immunohistochemical techniques, the authors observed the distribution and localization of IgA and secretory component (SC) in normal and hepatolithiasis livers, and measured the serum level of IgA by means of sandwich enzyme immunoassay (EIA). It was found that in normal livers positive reaction for SC and IgA could only found in epithelial cells of biliary canals. While in hepatolithiasis livers strong positive reaction for IgA and SC were also found in dilated bile canaliculi and the sinusoids. These results suggest that the epithelia of biliary canals take part in the formation and transferring of IgA and the backflow of IgA into blood stream under high pressure may cause hyper SIg A nemia.