Noppe C, Wachtel H C, Bernimoulin J P, Ebert-Kayser K
Polikliniken Nord für Zahn-, Mund- und Kieferheilkunde, Freie Universität Berlin.
Dtsch Zahnarztl Z. 1990 Oct;45(10):617-20.
In this study 40 patients with adult periodontitis received periodontal therapy with ePTFE membranes according to the principle of guided tissue regeneration. Membranes were subgingivally implanted for a period of 4 to 6 weeks. The tissue response was examined clinically and, in 7 cases, also histologically. After removal of the membranes, the membranes themselves and biopsies of the underlying regenerated tissue were prepared for light- and transmission electron microscopy. Clinically most cases showed membrane exposure with recessions and gingival pockets between membrane and gingiva. Histologically all exposed parts of the membranes were contaminated by microorganisms. In the superficial layers of the biopsies microorganisms were found between neutrophils, degenerated collagen fibrils and necrotic cell components.
在本研究中，40例成人牙周炎患者根据引导组织再生原理接受了膨体聚四氟乙烯（ePTFE）膜牙周治疗。将膜植入龈下4至6周。对组织反应进行了临床检查，7例还进行了组织学检查。去除膜后，对膜本身及下方再生组织的活检标本进行光镜和透射电镜检查。临床上大多数病例显示膜暴露，膜与牙龈之间有退缩和龈袋。组织学上，膜的所有暴露部分均被微生物污染。在活检标本的表层，在中性粒细胞、变性胶原纤维和坏死细胞成分之间发现了微生物。
