溶剂暴露个体淋巴细胞中的表观遗传改变。

Epigenetic changes in lymphocytes of solvent-exposed individuals.

机构信息

Katholieke Universiteit Leuven, Occupational, Environmental & Insurance Medicine, Kapucijnenvoer 35/5, Leuven, Belgium.

出版信息

Epigenomics. 2012 Jun;4(3):269-77. doi: 10.2217/epi.12.23.

DOI:10.2217/epi.12.23

PMID:22690663

Abstract

AIM

We investigated global DNA methylation alterations in lymphocytes of solvent workers and chronic toxic encephalopathy (CTE) patients and explored potential gene-environment interactions for GST. POPULATION & METHODS: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients.

RESULTS

We found a global DNA hypermethylation in the solvent-exposed population compared with the referents (p = 0.001, r = -0.544). Global DNA methylation was negatively associated with exposure. Furthermore, GSTP1 genotypic polymorphism was found to be significantly associated (p = 0.033) with global DNA hypomethylation, which indicates a potential role for gene-environment interaction in the etiology of solvent-induced neurobehavioral disorders.

CONCLUSION

This study indicates that solvent-induced DNA methylation alterations have an impact on neurotoxicity and development of CTE.

摘要

目的

我们研究了溶剂作业工人和慢性中毒性脑症（CTE）患者淋巴细胞中的全基因组 DNA 甲基化改变，并探讨了 GST 的潜在基因-环境相互作用。

人群和方法

在 41 名对照者、128 名溶剂作业工人和 23 名 CTE 患者中进行了一项横断面研究。

结果

我们发现暴露于溶剂的人群与对照者相比存在全基因组 DNA 高甲基化（p = 0.001，r = -0.544）。全基因组 DNA 甲基化与暴露呈负相关。此外，还发现 GSTP1 基因多态性与全基因组低甲基化显著相关（p = 0.033），表明基因-环境相互作用可能在溶剂引起的神经行为障碍的发病机制中起作用。