Department of Neurology, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands.
Acta Neurol Scand. 2013 Feb;127(2):103-8. doi: 10.1111/j.1600-0404.2012.01686.x. Epub 2012 Jun 12.
The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy. The aim of this study was to evaluate possible adverse effects of the diet on cognition, behavior, psychosocial adjustment, and quality of life in school-aged children and adolescents.
Fifteen subjects were assessed before diet initiation. After approximately 6 months, on diet treatment 11 patients (73%) were reassessed. We used a combination of individually administered psychological tests for the children and parent report questionnaires.
Five of 15 patients had a seizure reduction of more than 50%. Cognition showed a small trend toward improvement in most patients. Psychosocial adjustment, on the other hand, showed small trends toward worsening. For mood, two areas showed a larger change, revealing more mood problems although this was not on a statistically significant level.
In this small group of children, there is no indication that the KD has a negative impact on cognition or social adaptation at short term. There is a tendency toward an increase in mood problems.
生酮饮食（KD）越来越多地用于治疗难治性癫痫。本研究的目的是评估饮食对学龄儿童和青少年认知、行为、心理社会适应和生活质量的潜在不良影响。
15 名受试者在开始饮食前进行评估。大约 6 个月后，在饮食治疗 11 名患者（73%）中重新评估。我们使用儿童个体 administered 心理测试和家长报告问卷的组合。
15 名患者中有 5 名癫痫发作减少了 50%以上。认知在大多数患者中显示出略有改善的趋势。另一方面，心理社会适应显示出略有恶化的趋势。对于情绪，有两个领域显示出更大的变化，尽管这在统计学上没有意义，但情绪问题更多。
在这一小群儿童中，没有迹象表明 KD 在短期内对认知或社会适应有负面影响。情绪问题有增加的趋势。
