Mir F, Fontaine E, Reyes-Gomez E, Carlus M, Fontbonne A
Centre d'Études en Reproduction des Carnivores, Alfort Veterinary School, Maisons Alfort, France.
J Small Anim Pract. 2012 Jul;53(7):419-22. doi: 10.1111/j.1748-5827.2012.01224.x. Epub 2012 Jun 12.
A stud dog was presented for acquired infertility. Haematospermia and teratozoospermia were found on two ejaculates 2 weeks apart. A presumptive diagnosis of prostatitis was made follo-wing ultrasound examination. An ultrasound-guided needle core biopsy was performed under general anaesthesia, revealing a mild chronic macrophagic and plasma cell prostatitis with intracytoplasmic amastigotes consistent with Leishmania spp. infection. Presence of Leishmania infantum, Leishmania donovani or Leishmania chagasi was confirmed by polymerase chain reaction in seminal plasma. Serology and serum protein electrophoresis confirmed the diagnosis of a subclinical active systemic leishmaniasis. A meglumine antimoniate and allopurinol treatment was given which clearly improved within 3 months both general condition and the quality of sperm. To the authors' knowledge, this is the first reported case of a prostatitis secondary to a Leishmania spp. infection. Subclinical systemic leishmaniasis should be considered in the differential diagnosis of infertility in dogs suffering from semen alterations.
一只种公犬因后天性不育前来就诊。在间隔两周采集的两份精液样本中均发现了血精和畸形精子症。超声检查后初步诊断为前列腺炎。在全身麻醉下进行了超声引导下的针芯活检，结果显示为轻度慢性巨噬细胞性和浆细胞性前列腺炎，胞浆内可见无鞭毛体，符合利什曼原虫属感染。通过聚合酶链反应在精浆中确认存在婴儿利什曼原虫、杜氏利什曼原虫或恰加斯利什曼原虫。血清学和血清蛋白电泳确诊为亚临床活动性系统性利什曼病。给予葡甲胺锑酸盐和别嘌呤醇治疗，3个月内犬的总体状况和精子质量均明显改善。据作者所知，这是首例报道的由利什曼原虫属感染继发前列腺炎的病例。对于精液异常的不育犬，鉴别诊断时应考虑亚临床系统性利什曼病。
