Division of Dermatology and Cutaneous Sciences, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Dermatol Surg. 2012 Sep;38(9):1461-8. doi: 10.1111/j.1524-4725.2012.02482.x. Epub 2012 Jun 12.
There have only been a few population-based, epidemiologic studies assessing dermatofibrosarcoma protuberans (DFSP).
To assess the epidemiology of DFSP in Alberta, Canada, over a 20-year period.
A population-based, retrospective analysis of all cases of DFSP in Alberta was conducted using data from the Alberta Cancer Registry. Sex-, age-, and anatomical location-specific incidence rates and trends were determined.
The overall age-standardized incidence rate of DFSP remained stable at 0.93 per 100,000. DFSP prevalence was highest in individuals aged 20 to 39 (46.8%), followed by those aged 40 to 59 (34.0%), 60 and older (14.7%), and lastly younger than 20 (4.5%). The mean age at diagnosis was 41.1 (women) and 43.1 (men). The incidence of DFSP in men and women has shown a dramatic shift such that incidence in women has increased 3.2% per year, whereas in men it has decreased 2.7% per year. In women, DFSP incidence increased on the trunk and decreased on the upper extremities.
The age-standardized incidence of DFSP observed is nearly twice as high as previously reported and has remained stable. The incidence is increasing in women and decreasing in men. DFSP primarily affects young to middle-aged adults and most commonly presents on the trunk.
仅有少数几项基于人群的流行病学研究评估了隆凸性皮肤纤维肉瘤（DFSP）。
在 20 年的时间里，评估加拿大艾伯塔省 DFSP 的流行病学情况。
使用艾伯塔癌症登记处的数据，对艾伯塔省所有 DFSP 病例进行了一项基于人群的回顾性分析。确定了特定性别、年龄和解剖部位的发病率和趋势。
DFSP 的总体年龄标准化发病率保持稳定，为每 10 万人中有 0.93 人。DFSP 的流行率在 20 至 39 岁人群中最高（46.8%），其次是 40 至 59 岁人群（34.0%）、60 岁及以上人群（14.7%）以及 20 岁以下人群（4.5%）。诊断时的平均年龄为女性 41.1 岁，男性 43.1 岁。男性和女性中 DFSP 的发病率都发生了显著变化，女性的发病率每年增加 3.2%，而男性则每年减少 2.7%。在女性中，DFSP 的发病率在躯干上增加，在上肢上减少。
观察到的 DFSP 年龄标准化发病率几乎是先前报道的两倍，且保持稳定。发病率在女性中增加，在男性中减少。DFSP 主要影响年轻至中年成年人，最常见于躯干。
