Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
J Biol Regul Homeost Agents. 2012 Jan-Mar;26(1 Suppl):S19-25.
FEV1 is considered an important parameter for asthma diagnosis and follow-up. However, it has been proposed that FEF25-75 could be more sensitive than FEV1 to detect slight airways obstruction. Bronchial reversibility defined by positive response to bronchodilation test. The aim of the present study was to define whether an impaired FEF25-75 value (less than 65 percent of predicted) may be predictive for reversibility in a large cohort of allergic children with rhinitis or asthma. Six hundred allergic children were recruited: 300 with controlled asthma and 300 with allergic rhinitis. All of them were evaluated by performing spirometry, bronchodilation test, and skin prick test. Two predictors were significantly associated with bronchial reversibility: i) an impaired FEF25-75 value (less than 65 percent of predicted), and ii) sensitization to perennial allergens. It was more relevant in children with rhinitis (ORAdj:8.9 and 2.2 respectively). In conclusion, this study, conducted in real life, could suggest that an impaired FEF25-75 value (less than 65 percent of predicted) may be considered a reliable marker of bronchial reversibility, mainly in children with allergic rhinitis.
FEV1 被认为是哮喘诊断和随访的重要参数。然而，有人提出 FEF25-75 可能比 FEV1 更敏感，能够检测到轻微的气道阻塞。支气管舒张试验阳性反应定义为支气管可逆性。本研究旨在确定在患有鼻炎或哮喘的大量过敏儿童中，FEF25-75 值降低（低于预计值的 65%）是否可预测支气管可逆性。共招募了 600 名过敏儿童：300 名哮喘控制良好的儿童和 300 名过敏性鼻炎儿童。所有儿童均通过进行肺量测定、支气管舒张试验和皮肤点刺试验进行评估。有两个预测因素与支气管可逆性显著相关：i）FEF25-75 值降低（低于预计值的 65%），ii）对常年过敏原的致敏。在鼻炎儿童中更相关（ORAdj：8.9 和 2.2）。总之，这项在现实生活中进行的研究表明，FEF25-75 值降低（低于预计值的 65%）可能被认为是支气管可逆性的可靠标志物，主要在过敏性鼻炎儿童中。
