Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62250, Morelos, Mexico.
Peptides. 2013 Mar;41:87-93. doi: 10.1016/j.peptides.2012.05.023. Epub 2012 Jun 9.
Bacillus thuringiensis bacteria produce different insecticidal proteins known as Cry and Cyt toxins. Among them the Cyt toxins represent a special and interesting group of proteins. Cyt toxins are able to affect insect midgut cells but also are able to increase the insecticidal damage of certain Cry toxins. Furthermore, the Cyt toxins are able to overcome resistance to Cry toxins in mosquitoes. There is an increasing potential for the use of Cyt toxins in insect control. However, we still need to learn more about its mechanism of action in order to define it at the molecular level. In this review we summarize important aspects of Cyt toxins produced by Bacillus thuringiensis, including current knowledge of their mechanism of action against mosquitoes and also we will present a primary sequence and structural comparison with related proteins found in other pathogenic bacteria and fungus that may indicate that Cyt toxins have been selected by several pathogenic organisms to exert their virulence phenotypes.
苏云金芽孢杆菌产生不同的杀虫蛋白，称为 Cry 和 Cyt 毒素。其中 Cyt 毒素是一类特殊且有趣的蛋白。Cyt 毒素不仅能影响昆虫中肠细胞，还能增强某些 Cry 毒素的杀虫效果。此外，Cyt 毒素还能克服蚊子对 Cry 毒素的抗性。Cyt 毒素在昆虫防治方面具有越来越大的应用潜力。然而，我们仍需要更多地了解其作用机制，以便在分子水平上对其进行定义。在这篇综述中，我们总结了苏云金芽孢杆菌产生的 Cyt 毒素的重要方面，包括其对蚊子的作用机制的最新知识，我们还将对与其他致病性细菌和真菌中发现的相关蛋白进行一级序列和结构比较，这可能表明 Cyt 毒素已被几种致病性生物体选择来发挥其毒力表型。
