Division of Medicine, Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands.
Epidemiol Infect. 2013 Apr;141(4):847-51. doi: 10.1017/S0950268812001203. Epub 2012 Jun 13.
The Netherlands experienced an unprecedented outbreak of Q fever between 2007 and 2010. The Jeroen Bosch Hospital (JBH) in 's-Hertogenbosch is located in the centre of the epidemic area. Based on Q fever screening programmes, seroprevalence of IgG phase II antibodies to Coxiella burnetii in the JBH catchment area was 10·7% [785 tested, 84 seropositive, 95% confidence interval (CI) 8·5-12·9]. Seroprevalence appeared not to be influenced by age, gender or area of residence. Extrapolating these data, an estimated 40 600 persons (95% CI 32 200-48 900) in the JBH catchment area have been infected by C. burnetii and are, therefore, potentially at risk for chronic Q fever. This figure by far exceeds the nationwide number of notified symptomatic acute Q fever patients and illustrates the magnitude of the Dutch Q fever outbreak. Clinicians in epidemic Q fever areas should be alert for chronic Q fever, even if no acute Q fever is reported.
荷兰在 2007 年至 2010 年期间经历了一场前所未有的 Q 热疫情。位于'斯赫滕博赫的杰罗恩·博世医院（JBH）位于疫情中心。基于 Q 热筛查计划，JBH 集水区 IgG 二期抗体对科克斯氏体的血清流行率为 10.7%[785 人检测，84 人呈阳性，95%置信区间（CI）8.5-12.9]。血清流行率似乎不受年龄、性别或居住区域的影响。根据这些数据推断，JBH 集水区约有 40600 人（95%CI32200-48900）感染了科克斯氏体，因此可能患有慢性 Q 热。这一数字远远超过了全国报告的有症状急性 Q 热患者数量，说明了荷兰 Q 热疫情的严重程度。在爆发 Q 热的流行地区，临床医生即使没有报告急性 Q 热，也应该警惕慢性 Q 热。
