Zangiabadi N, Shafiee K, Alavi K H, Assadi A R, Damavandi M
Neuroscience Research Center, Kerman University of Medical Sciences Kerman, Iran.
Minerva Endocrinol. 2012 Jun;37(2):195-200.
Statins are widely used amongst diabetic patients. Recently, it has been proposed that they may exert many beneficial effects on vascular function regardless of their cholesterol lowering action. There are also growing concerns about statins-induced polyneuropathy in diabetic patients. As far as we know, this is the first clinical trial that has studied the effect of atorvastatin on electrophysiological parameters in diabetic neuropathy.
This was a randomized, double-blind, placebo-controlled clinical trial that assessed nerve conduction velocity (NCV) parameters after a six-month therapy with atorvastatin, 20 mg per day.
Although there was an 11% difference in Motor to F-wave conduction velocity ratio (M/F ratio) between the studied group and the controls, this difference was not statistically significant. Motor conduction velocity (MCV) significantly improved by 5% (P<0.05) and the F wave was not significantly deteriorated.
In conclusion, treatment with statins may have a beneficial effect on diabetic neuropathy electrophysiological changes, at least in the short-term.
他汀类药物在糖尿病患者中广泛使用。最近，有人提出它们可能对血管功能产生许多有益作用，而与它们的降胆固醇作用无关。糖尿病患者中他汀类药物引起的多发性神经病也日益受到关注。据我们所知，这是第一项研究阿托伐他汀对糖尿病神经病变电生理参数影响的临床试验。
这是一项随机、双盲、安慰剂对照的临床试验，评估了每天服用20毫克阿托伐他汀进行六个月治疗后的神经传导速度（NCV）参数。
虽然研究组与对照组之间的运动至F波传导速度比值（M/F比值）存在11%的差异，但该差异无统计学意义。运动传导速度（MCV）显著提高了5%（P<0.05），且F波无明显恶化。
总之，他汀类药物治疗可能至少在短期内对糖尿病神经病变的电生理变化有有益作用。
