Uma N, Fakurazi S, Hairuszah I
Department of Human Anatomy, 43400 UPM Serdang, Selangor Malaysia.
Malays J Nutr. 2010 Aug;16(2):293-307. Epub 2010 Aug 15.
This study investigated the role of antioxidant enzyme system following crude hydroethanolic extract of Moringa oleifera leaves (MO) in acute paracetamol (PCM) induced hepatotoxicity. Hydroethanolic extract (80%) of MO (200 mg/kg and 800 mg/kg; p.o) was pre-administered before a single oral dose of 3 g/kg PCM intoxication to male Sprague-Dawley rats. Pre-treatment of the extract was found to have reduced lipid peroxidation level when compared to the group treated with PCM only. The level of glutathione peroxidase (GPx), glutathione-Stransferase (GST) and glutathione reductase (GR) was restored to near normal in groups that were pre-treated with MO. Histopathological studies have further confirmed the hepatoprotective activity of MO compared to group treated with PCM only. The results obtained were comparable to silymarin (200 mg/kg; p.o). The MO extract was found to have significantly protected the liver against toxicity following PCM intoxication by enhancing the level of antioxidant enzyme activity.
本研究调查了辣木叶片粗乙醇提取物（MO）在急性扑热息痛（PCM）诱导的肝毒性中抗氧化酶系统的作用。在给雄性Sprague-Dawley大鼠单次口服3 g/kg PCM致中毒前，预先给予MO的乙醇提取物（80%，200 mg/kg和800 mg/kg；口服）。与仅用PCM治疗的组相比，发现提取物预处理可降低脂质过氧化水平。在预先用MO处理的组中，谷胱甘肽过氧化物酶（GPx）、谷胱甘肽-S-转移酶（GST）和谷胱甘肽还原酶（GR）的水平恢复到接近正常。组织病理学研究进一步证实了与仅用PCM治疗的组相比，MO具有肝保护活性。获得的结果与水飞蓟宾（200 mg/kg；口服）相当。发现MO提取物通过提高抗氧化酶活性水平，对PCM中毒后的肝脏具有显著的保护作用，使其免受毒性。
