基于鸟嘌呤适体酶的合成哺乳动物核糖开关。
Synthetic mammalian riboswitches based on guanine aptazyme.
机构信息
Department of Biomedical Engineering, University of California Davis, 451 Health Sciences Drive, Davis, CA 95616, USA.
出版信息
Chem Commun (Camb). 2012 Jul 21;48(57):7215-7. doi: 10.1039/c2cc33140c. Epub 2012 Jun 13.
PMID:22692003
Abstract
Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.
摘要
变构锤头核酶（aptazymes）被鸟嘌呤激活，用于顺式和反式调控哺乳动物基因表达。两种机制不同的核糖开关的共表达导致基因表达的动态范围得到改善。
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