伏隔核壳部多巴胺受体活性增加可改善戒断期间的焦虑。
Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal.
机构信息
Graduate Program in Neuroscience, Minneapolis, MN, USA.
出版信息
Neuropsychopharmacology. 2012 Oct;37(11):2405-15. doi: 10.1038/npp.2012.97. Epub 2012 Jun 13.
Abstract
A number of lines of evidence suggest that negative emotional symptoms of withdrawal involve reduced activity in the mesolimbic dopamine system. This study examined the contribution of dopaminergic signaling in structures downstream of the ventral tegmental area to withdrawal from acute morphine exposure, measured as potentiation of the acoustic startle reflex. Systemic administration of the general dopamine receptor agonist apomorphine or a cocktail of the D1-like receptor agonist SKF82958 and the D2-like receptor agonist quinpirole attenuated potentiated startle during morphine withdrawal. This effect was replicated by apomorphine infusion into the nucleus accumbens shell. Finally, apomorphine injection was shown to relieve startle potentiation during nicotine withdrawal and conditioned place aversion to morphine withdrawal. These results suggest that transient activation of the ventral tegmental area mesolimbic dopamine system triggers the expression of anxiety and aversion during withdrawal from multiple classes of abused drugs.
摘要
有大量证据表明，戒断的负面情绪症状涉及中脑边缘多巴胺系统活动减少。本研究检测了腹侧被盖区下游结构的多巴胺能信号传导对急性吗啡暴露戒断的贡献，其通过声惊反射增强来衡量。全身给予通用多巴胺受体激动剂阿朴吗啡或 D1 样受体激动剂 SKF82958 和 D2 样受体激动剂喹吡罗的鸡尾酒可减轻吗啡戒断时的惊跳增强。阿朴吗啡在伏隔核壳内的输注可复制这种作用。最后，阿朴吗啡注射显示可缓解尼古丁戒断时的惊跳增强和对吗啡戒断的条件性位置厌恶。这些结果表明，腹侧被盖区中脑边缘多巴胺系统的短暂激活会引发多种滥用药物戒断时的焦虑和厌恶表达。
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