Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.
J Am Soc Mass Spectrom. 2012 Sep;23(9):1512-21. doi: 10.1007/s13361-012-0419-6. Epub 2012 Jun 13.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu .
氢/氘交换质谱（HDX-MS）是一种用于研究蛋白质构象和动力学的成熟方法。尽管已经有许多软件包解决了 HDX-MS 的数据分析挑战，但仍需要新的计算工具来跟上该技术的改进方法和通量。为了满足这些需求，我们报告了一个名为 HDX Workbench 的集成桌面程序，该程序有助于自动化、管理、可视化和统计比较大型 HDX 数据集。使用该软件，可以以生成的速度实现经过验证的数据分析。该应用程序可在项目主页 http://hdx.florida.scripps.edu 上获得。
