恶性肿瘤的热灌注治疗

Heat perfusion for malignancy.

作者信息

Patel Chandrakant Vitthal, Kinare Suman G, Sen Prafullakumar K

机构信息

K.E.M. Hospital, Mumbai, India.

出版信息

Indian J Surg Oncol. 2010 Dec;1(4):303-4. doi: 10.1007/s13193-011-0043-0. Epub 2011 Mar 4.

DOI:10.1007/s13193-011-0043-0

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3244257/

Abstract

Hyperthermia, total anoxia and low pH have shown selective lethal effect on malignant cells. A perfusion system was devised to combine these modalities and was tried in 4 cases of advanced malignancy. A perfusion lasting for 45 minutes was found safe for normal tissue and yet selectively injurious to malignant cells. Technically this is a very simple procedure and its principles can be utilized in regional infusion also. Though the clinical material is scanty,the method deserves further trial.

摘要

高温、完全缺氧和低pH值已显示出对恶性细胞有选择性致死作用。设计了一种灌注系统来结合这些方式，并在4例晚期恶性肿瘤患者中进行了试验。发现持续45分钟的灌注对正常组织是安全的，但对恶性细胞有选择性损伤。从技术上讲，这是一个非常简单的程序，其原理也可用于区域灌注。尽管临床资料有限，但该方法值得进一步试验。

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