Roemer R B, Cetas T C, Oleson J R, Halac S, Matloubieh A Y
Radiat Res. 1984 Dec;100(3):450-72.
A method for comparing the relative abilities of different hyperthermia heating modalities to properly heat tumors has been developed using solutions of the bio-heat transfer equation. A single measure, the range of absorbed powers that gives acceptable tissue temperature distributions, is used to characterize the ability of a given heating technique to heat a given tumor. An acceptable tissue temperature distribution is one for which (a) the temperatures in the coolest regions of the tumor are above a minimum therapeutic value, (b) the temperatures in the hottest regions of the tumor do not exceed a maximum clinically acceptable value, and (c) the normal tissue temperatures do not exceed maximum clinically acceptable levels. This measure can be interpreted directly in clinical terms as the range of power settings on the power indicator of a heating device for which acceptable tumor heatings will occur. This paper describes the basis of the method and investigates the role of tumor blood perfusion patterns in determining the size of the acceptable power range. Three tumor perfusion patterns are investigated: uniform tumor perfusion, a concentric annulli perfusion model in which the tumor consists of a necrotic core surrounded by two concentric layers of increased perfusion, and a random perfusion distribution model. The results show that, in general, the uniform and annular perfusion models serve as bracketing case patterns. That is, they give acceptable power range values that are upper and lower limits of the acceptable power ranges obtained for the random perfusion patterns. The method is applied to heating patterns that simulate those obtained from a variety of different available heating techniques, and it is found to be valid for all cases studied. The role of normal tissue limiting conditions is also investigated.
一种利用生物热传递方程的解来比较不同热疗加热方式对肿瘤进行适当加热的相对能力的方法已经开发出来。使用一个单一的指标，即能给出可接受的组织温度分布的吸收功率范围，来表征给定加热技术对给定肿瘤进行加热的能力。可接受的组织温度分布是指这样一种情况：(a)肿瘤最冷区域的温度高于最低治疗值；(b)肿瘤最热区域的温度不超过临床可接受的最大值；(c)正常组织温度不超过临床可接受的最高水平。这个指标可以直接从临床角度解释为加热设备功率指示器上能实现可接受肿瘤加热的功率设置范围。本文描述了该方法的基础，并研究了肿瘤血液灌注模式在确定可接受功率范围大小方面的作用。研究了三种肿瘤灌注模式：均匀肿瘤灌注、一种同心环灌注模型（其中肿瘤由坏死核心和围绕其的两层同心增加灌注层组成）以及随机灌注分布模型。结果表明，一般来说，均匀灌注和环形灌注模型起到了界定案例模式的作用。也就是说，它们给出的可接受功率范围值是随机灌注模式所获得的可接受功率范围的上限和下限。该方法应用于模拟从各种不同现有加热技术获得的加热模式，并且发现对所有研究案例都是有效的。还研究了正常组织限制条件的作用。
