拉索菌素，一种来自拉索菌属的萘并吡喃酮

Lasionectrin, a naphthopyrone from a Lasionectria sp.

机构信息

Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, E-18100 Armilla, Granada, Spain.

出版信息

J Nat Prod. 2012 Jun 22;75(6):1228-30. doi: 10.1021/np3002942. Epub 2012 Jun 13.

DOI:10.1021/np3002942

PMID:22694295

Abstract

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.

摘要

从赤道几内亚森林落叶中分离到的一株暂定为 Lasionectria 种的枝顶孢属真菌（子囊菌门，腔孢纲）发酵液中分离得到一个新的萘并吡喃酮衍生物 lasionectrin（1）。通过结合包括 UV、（+）-HRESIMS 以及 1D 和 2D NMR 光谱在内的光谱技术，并与相关真菌代谢产物的已发表数据进行比较，确定了其结构。化合物 1 对恶性疟原虫的生长具有抑制作用，其 IC50 值为 11 μM。