蜘蛛致病真菌 Torrubiella sp. BCC 2165 中的吡啶酮和四氢酸生物碱。

Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165.

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, Thailand.

出版信息

J Nat Prod. 2010 Dec 27;73(12):2057-60. doi: 10.1021/np100492j. Epub 2010 Nov 23.

DOI:10.1021/np100492j

PMID:21090800

Abstract

Torrubiellones A-D (1-4), new pyridone and tetramic acid alkaloids, were isolated from the spider pathogenic fungus Torrubiella sp. BCC 2165. Torrubiellone A (1) exhibited antimalarial activity with an IC(50) value of 8.1 μM, while it showed very weak cytotoxic activity.

摘要

托鲁比埃洛酮 A-D（1-4），新型吡啶酮和四氢酸生物碱，从蜘蛛致病真菌托鲁比埃洛菌 BCC 2165 中分离得到。托鲁比埃洛酮 A（1）表现出抗疟活性，IC（50）值为 8.1 μM，而其细胞毒性活性非常弱。