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在重症联合免疫缺陷(SCID)小鼠中建立功能性T细胞不会导致妊娠终止。

Establishment of functional T cells in SCID mice does not lead to termination of pregnancy.

作者信息

Hetherington C M, Dresser D W

机构信息

National Institute for Medical Research, London U.K.

出版信息

Immunology. 1990 Nov;71(3):449-53.

PMID:2269480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384447/
Abstract

Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.

摘要

将同基因(CB20)胸腺和脾脏T细胞转移至SCID小鼠体内,通过流式细胞术分析证实这些T细胞存在,并通过其排斥第三方皮肤移植物的能力证明其具有功能,但这些T细胞并不会导致同基因或异基因妊娠出现可检测到的失败情况。除非污染T细胞接种物的少量B细胞能够产生阻断抗体反应,否则可以得出结论,这些结果表明体液(“阻断抗体”)反应对于成功妊娠并非必不可少。

相似文献

1
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Immunology. 1990 Nov;71(3):449-53.
2
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本文引用的文献

1
A severe combined immunodeficiency mutation in the mouse.小鼠中的一种严重联合免疫缺陷突变。
Nature. 1983 Feb 10;301(5900):527-30. doi: 10.1038/301527a0.
2
Defective induction of antigen-reactive proliferating T cells in B cell-deprived mice. II. Anti-mu treatment affects the initiation and recruitment of T cells.B细胞缺失小鼠中抗原反应性增殖T细胞的诱导缺陷。II. 抗μ治疗影响T细胞的起始和募集。
Eur J Immunol. 1983 Feb;13(2):167-71. doi: 10.1002/eji.1830130214.
3
B cell-deprived mice lack functional expression of certain T suppressor cell subsets.缺乏B细胞的小鼠某些T抑制细胞亚群缺乏功能性表达。
J Mol Cell Immunol. 1984;1(3):167-76.
4
Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.用兔抗小鼠μ链抗体进行长期治疗会改变小鼠抑制性T细胞因子特征性的免疫球蛋白重链限制。
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3846-50. doi: 10.1073/pnas.81.12.3846.
5
The abnormal function of T cells in chronically anti-mu-treated mice with no mature B lymphocytes.在没有成熟B淋巴细胞的慢性抗μ治疗小鼠中T细胞的异常功能。
Eur J Immunol. 1984 May;14(5):476-82. doi: 10.1002/eji.1830140517.
6
Preparation and properties of a cytotoxic monoclonal rat anti-mouse Thy-1 antibody.一种细胞毒性大鼠抗小鼠Thy-1单克隆抗体的制备及其特性
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Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor.一种血清因子消除针对抗原性异源小鼠胚胎细胞的细胞免疫反应。
Nature. 1969 Nov 29;224(5222):914-5. doi: 10.1038/224914a0.
8
Suppression of immunoglobulin G synthesis as a result of antibody-mediated suppression of immunoglobulin M synthesis in chickens.抗体介导抑制鸡免疫球蛋白M合成导致免疫球蛋白G合成受抑制。
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1918-25. doi: 10.1073/pnas.67.4.1918.
9
Allogeneic pregnancy in B-lymphocyte deprived CBA/Ca mice--effects on maternal lymphoid organs and fetal survival.B淋巴细胞缺失的CBA/Ca小鼠的同种异体妊娠——对母体淋巴器官和胎儿存活的影响。
Dev Comp Immunol. 1985 Fall;9(4):709-17. doi: 10.1016/0145-305x(85)90035-7.
10
Lack of a requirement for a maternal humoral immune response to establish or maintain successful allogeneic pregnancy.建立或维持成功的同种异体妊娠并不需要母体的体液免疫反应。
Transplantation. 1985 Oct;40(4):372-5. doi: 10.1097/00007890-198510000-00006.