在重症联合免疫缺陷（SCID）小鼠中建立功能性T细胞不会导致妊娠终止。
Establishment of functional T cells in SCID mice does not lead to termination of pregnancy.
作者信息
Hetherington C M, Dresser D W
机构信息
National Institute for Medical Research, London U.K.
出版信息
Immunology. 1990 Nov;71(3):449-53.
Abstract
Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.
摘要
将同基因（CB20）胸腺和脾脏T细胞转移至SCID小鼠体内，通过流式细胞术分析证实这些T细胞存在，并通过其排斥第三方皮肤移植物的能力证明其具有功能，但这些T细胞并不会导致同基因或异基因妊娠出现可检测到的失败情况。除非污染T细胞接种物的少量B细胞能够产生阻断抗体反应，否则可以得出结论，这些结果表明体液（“阻断抗体”）反应对于成功妊娠并非必不可少。
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本文引用的文献
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A severe combined immunodeficiency mutation in the mouse.小鼠中的一种严重联合免疫缺陷突变。
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