淋巴因子激活的杀伤细胞上清液中的一种高分子量细胞毒性淋巴因子与转化生长因子β发生交叉反应。
A high molecular weight cytotoxic lymphokine in supernatants of lymphokine-activated killer cells cross-reacts with transforming growth factor beta.
作者信息
Larisch-Bloch S, Sterman B, Sulitzeanu D
机构信息
Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
出版信息
Immunol Lett. 1990 Nov;26(2):189-92. doi: 10.1016/0165-2478(90)90144-f.
Supernatants of lymphokine-activated killer (LAK) cells were highly cytotoxic for melanoma A375 cells. A high-molecular-weight fraction was isolated from such supernatants by gel filtration on an S-300 Sephacryl column (Fraction 1; Fr1). The cytotoxic activity in Fr1 was heat- and acid-resistant and was completely abolished by a rabbit antibody against TGF-beta. We conclude that Fr1 contains TGF-beta or a cross-reactive molecule, associated with a high-molecular-weight carrier.
淋巴因子激活的杀伤（LAK）细胞的上清液对黑色素瘤A375细胞具有高度细胞毒性。通过在S-300 Sephacryl柱上进行凝胶过滤从此类上清液中分离出一种高分子量组分（组分1；Fr1）。Fr1中的细胞毒性活性耐热且耐酸，并被抗TGF-β的兔抗体完全消除。我们得出结论，Fr1含有与高分子量载体相关的TGF-β或交叉反应分子。
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