Thomas F, Bean K, London G, Danchin N, Pannier B
Centre d'investigations préventives et cliniques (IPC), 6, rue La Pérouse, 75116 Paris, France.
Ann Cardiol Angeiol (Paris). 2012 Jun;61(3):140-4. doi: 10.1016/j.ancard.2012.04.021. Epub 2012 May 23.
To evaluate incidence and determinants of arterial hypertension after 60 years.
Four thousand nine hundred and forty one subjects aged 60 years or above (2505 men: 64.2±4.2 years; 2436 women: 64.8±4.3 years) were explored two times at the IPC center, Paris, between 1992 and 2007, and were normotensive at the first visit (V1): systolic BP (SBP) less than 140mmHg and diastolic BP (DBP) less than 90mmHg without treatment. The delay between the two visits was 5.8±2.2 years. At the second visit, population was analysed as normotensives and hypertensives. An age-adjusted Anova compared groups.
In men, incidence of hypertension is 41.5% and 25.9% for isolated systolic hypertension. In women, incidences were 37.8% and 27.8% respectively. Baseline characteristics for V2-hypertensives showed higher SBP, DBP, BMI, heart rate, glycemia, ECG abnormalities thanV2-normotensives but they had lower physical activity. The determinants of hypertension were: SBP, age, BMI, DBP, glycemia, and lack of physical activity for this age class.
From 60 years old, 6-year incidence of hypertension is about 40% and 26% for isolated systolic hypertension, this latter being higher in women. Regular physical activity is protective.
评估60岁后动脉高血压的发病率及决定因素。
1992年至2007年期间,对巴黎IPC中心的4941名60岁及以上受试者(2505名男性:64.2±4.2岁;2436名女性:64.8±4.3岁)进行了两次调查,他们在首次就诊(V1)时血压正常:收缩压(SBP)低于140mmHg且舒张压(DBP)低于90mmHg,未经治疗。两次就诊之间的间隔为5.8±2.2年。在第二次就诊时,将人群分为血压正常者和高血压患者进行分析。采用年龄调整后的方差分析对各组进行比较。
男性高血压发病率为41.5%,单纯收缩期高血压发病率为25.9%。女性发病率分别为37.8%和27.8%。V2高血压患者的基线特征显示,其收缩压、舒张压、体重指数、心率、血糖、心电图异常均高于V2血压正常者,但身体活动较少。高血压的决定因素为:该年龄组的收缩压、年龄、体重指数、舒张压、血糖和缺乏身体活动。
60岁起,高血压6年发病率约为40%,单纯收缩期高血压发病率约为26%,后者在女性中更高。规律的身体活动具有保护作用。