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目前，18kDa 转位蛋白（TSPO）作为神经炎症和神经退行性疾病正电子发射断层扫描（PET）成像的分子靶点。

Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases.

机构信息

CEA, I2BM, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401, Orsay, France,

出版信息

Insights Imaging. 2012 Feb;3(1):111-9. doi: 10.1007/s13244-011-0128-x. Epub 2011 Oct 16.

DOI:10.1007/s13244-011-0128-x
PMID:22696004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3292648/
Abstract

Neuroinflammation is a process characterised by drastic changes in microglial morphology and by marked upregulation of the 18-kDa translocator protein (TSPO) on the mitochondria. The continual increase in incidence of neuroinflammation and neurodegenerative diseases poses a major health issue in many countries, requiring more innovative diagnostic and monitoring tools. TSPO expression may constitute a biomarker for brain inflammation that could be monitored by using TSPO tracers as neuroimaging agents. From medical imaging perspectives, this review focuses on the current concepts related to the TSPO, and discusses briefly on the status of its PET imaging related to neuroinflammation and neurodegenerative diseases in humans.

摘要

神经炎症是一种以小胶质细胞形态剧烈变化和线粒体 18kDa 移位蛋白（TSPO）显著上调为特征的过程。神经炎症和神经退行性疾病的发病率不断上升，在许多国家构成了一个主要的健康问题，需要更多创新的诊断和监测工具。TSPO 的表达可能构成大脑炎症的生物标志物，可以通过使用 TSPO 示踪剂作为神经影像学试剂来监测。从医学成像的角度来看，本综述重点介绍了与 TSPO 相关的当前概念，并简要讨论了其在人类神经炎症和神经退行性疾病中的 PET 成像现状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/517466f9ce09/13244_2011_128_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/29e7148b40bf/13244_2011_128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/e671d1186199/13244_2011_128_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/359b4c7c0a22/13244_2011_128_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/6146e1631134/13244_2011_128_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/81ef078d37f9/13244_2011_128_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/517466f9ce09/13244_2011_128_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/29e7148b40bf/13244_2011_128_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/e671d1186199/13244_2011_128_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/359b4c7c0a22/13244_2011_128_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/6146e1631134/13244_2011_128_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/81ef078d37f9/13244_2011_128_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb62/3292648/517466f9ce09/13244_2011_128_Fig6_HTML.jpg

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