线粒体呼吸链模型动力学研究的理论方法
Theoretical methods for study of kinetics of models of the mitochondrial respiratory chain.
作者信息
Hill T L, Chay T R
出版信息
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3203-7. doi: 10.1073/pnas.76.7.3203.
Abstract
In earlier work, Hill and Chance obtained exact steady-state kinetic properties for partial models of the mitochondrial respiratory chain with two isopotential pools and one four-state "site enzyme" between the two pools. That work is extended here to full models of the respiratory chain with four isopotential pools and three four-state site enzymes between pairs of pools. Because of the complexity of the model, exact calculations are no longer possible. Instead, we show, by means of some examples, the feasibility of using Monte Carlo calculations on all cases and numerical solution of thousands of kinetic differential equations in many cases.
摘要
在早期的工作中，希尔和钱斯获得了线粒体呼吸链部分模型的精确稳态动力学特性，该模型有两个等电位池以及两个池之间的一个四态“位点酶”。此处将该工作扩展到呼吸链的完整模型，其具有四个等电位池以及池对之间的三个四态位点酶。由于模型的复杂性，精确计算已不再可行。相反，我们通过一些示例表明，在所有情况下使用蒙特卡罗计算以及在许多情况下对数千个动力学微分方程进行数值求解是可行的。
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