Velden M, Karemaker J M, Wölk C, Schneider R
University of Osnabrück, F.R.G.
Int J Psychophysiol. 1990 Nov;10(1):85-93. doi: 10.1016/0167-8760(90)90049-j.
Since the now classical experiments by Brown and Eccles in 1934, the effect of a stimulation of the vagus nerve on the heart has been derived from changes in the length of cardiac periods. Based on a simple model for the genesis of heartbeats, it is shown that the procedure employed by Brown and Eccles gives a distorted picture of the actual vagal effect. A corrected procedure for inferring the vagal effect from changes in heart period length is proposed. This new procedure is applied to empirical data from animal experiments with direct stimulation of the vagus nerve. It is shown that, if the vagal effect depends on time of stimulation within the cardiac cycle (cycle time-dependency), single vagal effect curves for each time of stimulation within the cycle have to be constructed. Other data reduction procedures are reviewed with respect to their appropriateness for demonstrating cycle time-dependency.
自1934年布朗和埃克尔斯进行了具有里程碑意义的实验以来，迷走神经刺激对心脏的影响一直是通过心脏周期时长的变化来推导的。基于一个简单的心跳产生模型，研究表明布朗和埃克尔斯所采用的方法歪曲了迷走神经的实际作用效果。本文提出了一种从心脏周期时长变化推断迷走神经作用效果的修正方法。这种新方法被应用于直接刺激迷走神经的动物实验的经验数据。研究表明，如果迷走神经作用效果取决于心动周期内的刺激时间（周期时间依赖性），那么就必须构建心动周期内每次刺激时间的单个迷走神经作用效果曲线。还对其他数据简化方法在证明周期时间依赖性方面的适用性进行了综述。
