Laboratory Research Branch, Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Clin Appl Thromb Hemost. 2013 Jul-Aug;19(4):410-7. doi: 10.1177/1076029612448419. Epub 2012 Jun 12.
In addition to potentially sharing common pathogenesis and clinical manifestations, venous and arterial thromboses might have overlapping risk factors. To evaluate the family history of myocardial infarction (MI) as a risk factor for venous thromboembolism (VTE) among whites and blacks, we analyze data from the Genetic Attributes and Thrombosis Epidemiology (GATE) study. Results indicate that the association between VTE and a family history of MI is statistically significant only among whites (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.03-1.8), particularly when they have diabetes mellitus (OR = 3.1; 95% CI = 1.2-8.0). Among blacks, the association between VTE and a family history of MI is not statistically significant (OR = 1.2; 95% CI = 0.89-1.5) either among those with diabetes or those without diabetes. We conclude that a family history of MI is a risk factor for VTE among certain populations stratified by race and comorbid conditions.
除了可能具有共同的发病机制和临床表现外，静脉血栓形成和动脉血栓形成可能具有重叠的危险因素。为了评估心肌梗死 (MI) 家族史是否是白人及黑人静脉血栓栓塞症 (VTE) 的危险因素，我们分析了遗传特征与血栓形成流行病学 (GATE) 研究的数据。结果表明，VTE 与 MI 家族史之间的关联仅在白人中具有统计学意义（比值比 [OR] = 1.3；95%置信区间 [CI] = 1.03-1.8），尤其是当他们患有糖尿病时（OR = 3.1；95% CI = 1.2-8.0）。在黑人中，VTE 与 MI 家族史之间的关联无论是否存在糖尿病，在统计学上均无显著性（OR = 1.2；95% CI = 0.89-1.5）。我们得出结论，MI 家族史是某些按种族和合并症分层的人群发生 VTE 的危险因素。
