Danish Arrhythmia Research Center, Department of Cardiology B2142, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Circulation. 2010 May 4;121(17):1896-903. doi: 10.1161/CIRCULATIONAHA.109.921460. Epub 2010 Apr 19.
Studies have suggested a link between risk factors for atherosclerotic disease and venous thromboembolism (VTE), but results are heterogeneous. We sought to identify risk factors for VTE with a focus on risk factors for atherosclerotic disease.
Data were taken from the Copenhagen City Heart Study, a prospective cohort study of a random, age-stratified sample of people living in a defined area in Copenhagen, Denmark, started in 1976 with follow-up until 2007. First VTE (deep vein thrombosis and pulmonary embolism) diagnosis was retrieved from electronic national registries from study baseline to 2007. Of 18 954 subjects (median follow-up, 19.5 years) representing 360 399 person-years of follow-up, 969 subjects experienced at least 1 VTE, corresponding to a crude incidence rate of 2.69 (95% confidence interval [CI], 2.52 to 2.86) per 1000 person-years. The variables found to be significantly associated with VTE in a multivariable model adjusted for age and calendar time were as follows: body mass index (hazard ratio [HR] for >or=35 versus <20=2.10 [95% CI, 1.39 to 3.16]); smoking (HR for >or=25 g tobacco per day versus never smoker=1.52 [95% CI, 1.15 to 2.01]); gender (HR for men versus women=1.24 [95% CI, 1.08 to 1.42]); household income (HR for medium versus low=0.82 [95% CI, 0.70 to 0.95]); and diastolic blood pressure (HR for >100 versus <80 mm Hg=1.34 [95% CI, 1.08 to 1.66]). Other cardiovascular risk factors including total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not associated with VTE.
Obesity and smoking were both found to be important risk factors for VTE whereas total/high-density lipoprotein/low-density lipoprotein cholesterol levels, triglyceride levels, and diabetes mellitus were not.
研究表明，动脉粥样硬化疾病的危险因素与静脉血栓栓塞症（VTE）之间存在关联，但结果存在异质性。我们试图确定 VTE 的危险因素，重点关注动脉粥样硬化疾病的危险因素。
数据来自哥本哈根城市心脏研究，这是一项针对丹麦哥本哈根一个特定区域内随机、年龄分层人群的前瞻性队列研究，于 1976 年开始，随访至 2007 年。首次 VTE（深静脉血栓形成和肺栓塞）诊断从研究基线至 2007 年从电子国家登记处检索。在 18954 名受试者（中位随访时间为 19.5 年，代表 360399 人年的随访时间）中，有 969 名受试者至少经历了 1 次 VTE，粗发病率为 2.69（95%置信区间[CI]，2.52 至 2.86）/1000 人年。在调整年龄和日历时间的多变量模型中，与 VTE 显著相关的变量如下：体重指数（>或=35 与 <20 的比值比[HR]为 2.10[95%CI，1.39 至 3.16]）；吸烟（>或=25 克烟草/天与从不吸烟者的 HR 为 1.52[95%CI，1.15 至 2.01]）；性别（男性与女性的 HR 为 1.24[95%CI，1.08 至 1.42]）；家庭收入（中值与低值的 HR 为 0.82[95%CI，0.70 至 0.95]）；和舒张压（>100 与 <80mmHg 的 HR 为 1.34[95%CI，1.08 至 1.66]）。其他心血管危险因素，包括总/高密度脂蛋白/低密度脂蛋白胆固醇水平、甘油三酯水平和糖尿病，与 VTE 无关。
肥胖和吸烟均被认为是 VTE 的重要危险因素，而总/高密度脂蛋白/低密度脂蛋白胆固醇水平、甘油三酯水平和糖尿病则不是。
