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Locked in and out: a case of emerging basilar artery obstruction secondary to vertebral artery dissection thrombolysed with intravenous rt-PA.锁进与脱出：一例继发于椎动脉夹层的基底动脉闭塞经静脉注射重组组织型纤溶酶原激活剂溶栓的病例
BMJ Case Rep. 2011 May 12;2011:bcr1220103584. doi: 10.1136/bcr.12.2010.3584.
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[Locked-in syndrome due to a vertebral dissection and therapeutic options with intraarterial fibrinolysis in acute phase].[椎动脉夹层所致闭锁综合征及急性期动脉内溶栓治疗选择]
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Early thrombolysis in stroke due to basilar artery occlusion.基底动脉闭塞性卒中的早期溶栓治疗。
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Combined thrombolysis in posterior circulation stroke caused by bilateral vertebral artery dissection in squash player.壁球运动员双侧椎动脉夹层致后循环卒中的联合溶栓治疗。
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Early intravenous thrombolysis with recombinant tissue-type plasminogen activator in vertebrobasilar ischemic stroke.重组组织型纤溶酶原激活剂在椎基底动脉缺血性卒中早期静脉溶栓治疗中的应用
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本文引用的文献

1
Occlusion of the basilar artery; a clinical and pathological study.基底动脉闭塞；一项临床与病理学研究。
Brain. 1946 Jun;69(2):73-121. doi: 10.1093/brain/69.2.73.
2
Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study.基底动脉国际合作研究（BASICS）中急性基底动脉闭塞的治疗与结局：一项前瞻性注册研究
Lancet Neurol. 2009 Aug;8(8):724-30. doi: 10.1016/S1474-4422(09)70173-5. Epub 2009 Jul 3.
3
Extracranial carotid and vertebral artery dissection: a review.颅外颈动脉和椎动脉夹层：综述
Can J Neurol Sci. 2008 May;35(2):146-52. doi: 10.1017/s0317167100008556.
4
Neurological complications and aspects of basilar artery occlusive disease.基底动脉闭塞性疾病的神经并发症及相关方面
Neurologist. 2007 Nov;13(6):363-8. doi: 10.1097/01.nrl.0000257849.31167.4f.
5
Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis.基底动脉闭塞的治疗：比较动脉内溶栓和静脉溶栓的系统分析
Stroke. 2006 Mar;37(3):922-8. doi: 10.1161/01.STR.0000202582.29510.6b. Epub 2006 Jan 26.
6
Basilar occlusive disease: the descent of the feared foe?
Arch Neurol. 2004 Apr;61(4):471-2. doi: 10.1001/archneur.61.4.471.
7
Endovascular embolectomy of acute basilar artery occlusion.急性基底动脉闭塞的血管内取栓术
Neurology. 2003 Nov 25;61(10):1421-3. doi: 10.1212/wnl.61.10.1421.
8
Anticoagulants for preventing recurrence following presumed non-cardioembolic ischaemic stroke or transient ischaemic attack.用于预防疑似非心源性缺血性卒中或短暂性脑缺血发作后复发的抗凝剂。
Cochrane Database Syst Rev. 2003(1):CD000248. doi: 10.1002/14651858.CD000248.
9
Stroke or transient ischemic attacks with basilar artery stenosis or occlusion: clinical patterns and outcome.伴有基底动脉狭窄或闭塞的中风或短暂性脑缺血发作：临床模式与预后
Arch Neurol. 2002 Apr;59(4):567-73. doi: 10.1001/archneur.59.4.567.
10
Diffusion-weighted imaging and National Institutes of Health Stroke Scale in the acute phase of posterior-circulation stroke.后循环卒中急性期的扩散加权成像与美国国立卫生研究院卒中量表
Arch Neurol. 2001 Apr;58(4):621-8. doi: 10.1001/archneur.58.4.621.

锁进与脱出：一例继发于椎动脉夹层的基底动脉闭塞经静脉注射重组组织型纤溶酶原激活剂溶栓的病例

Locked in and out: a case of emerging basilar artery obstruction secondary to vertebral artery dissection thrombolysed with intravenous rt-PA.

作者信息

Al-Raweshidy Y H, Sinha D M, Coward L J, Guyler P C, O'Brien A

机构信息

Southend University Hospital, Southend, UK.

出版信息

BMJ Case Rep. 2011 May 12;2011:bcr1220103584. doi: 10.1136/bcr.12.2010.3584.

DOI:10.1136/bcr.12.2010.3584
PMID:22696744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3094800/
Abstract

The authors present a case in which intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) potentially saved a young man from locked-in syndrome or life threatening consequences. The patient presented with acute stroke secondary to vertebral artery dissection and was treated with intravenous rt-PA. There were no post thrombolysis complications and the patient left hospital with mild neurological symptoms. Our report suggests that in cases of acute posterior circulation stroke due to arterial dissection, treatment with intravenous thrombolysis is safe, practicable and effective.

摘要

作者介绍了一例病例，其中使用重组组织型纤溶酶原激活剂（rt-PA）进行静脉溶栓可能使一名年轻男子免于闭锁综合征或危及生命的后果。该患者因椎动脉夹层导致急性中风，并接受了静脉rt-PA治疗。溶栓后无并发症，患者出院时遗留轻度神经症状。我们的报告表明，对于因动脉夹层导致的急性后循环中风病例，静脉溶栓治疗是安全、可行且有效的。