Blanchard J, Ramamurthy S, Walsh N, Hoffman J, Schoenfeld L
J Pain Symptom Manage. 1990 Dec;5(6):357-61. doi: 10.1016/0885-3924(90)90030-n.
This double-blind, randomized study was designed to compare the effectiveness of intravenous regional sympatholysis using guanethidine, reserpine and normal saline. Twenty-one patients with reflex sympathetic dystrophy of an upper or lower extremity were enrolled and received intravenous regional blockade (IVRB) with one of the three medications. There was significant pain relief in all three groups at 30 min. There were no significant differences among the three groups in the degree of pain relief, the number of patients obtaining pain relief in the 30 min after the block, or the number of patients reporting more than 50% pain relief for more than 24 hr. The saline group's high rate of pain relief could be partially due to a mechanism of tourniquet-induced analgesia.
这项双盲随机研究旨在比较胍乙啶、利血平和生理盐水进行静脉局部交感神经阻滞的效果。纳入了21例上肢或下肢反射性交感神经营养不良患者，并用这三种药物之一进行静脉局部阻滞（IVRB）。三组在30分钟时均有显著的疼痛缓解。三组在疼痛缓解程度、阻滞30分钟内获得疼痛缓解的患者数量或报告疼痛缓解超过50%达24小时以上的患者数量方面均无显著差异。生理盐水组的高疼痛缓解率可能部分归因于止血带诱导的镇痛机制。
