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无支架生物瓣用于修复急性 A 型主动脉夹层。

Stentless root bioprosthesis for repair of acute type A aortic dissection.

机构信息

Department of Thoracic and Cardiovascular Surgery, Meijer Heart Center, Butterworth Hospital, Grand Rapids, Mich 49503, USA.

出版信息

J Thorac Cardiovasc Surg. 2013 Jun;145(6):1540-4. doi: 10.1016/j.jtcvs.2012.05.029. Epub 2012 Jun 13.

Abstract

OBJECTIVE

The superior hemodynamics and excellent long-term clinical performance of stentless xenografts are well described. However, the early and midterm clinical outcomes of stentless valves in patients with acute type A dissection are widely unknown. The current study evaluated the early and midterm clinical outcomes of stentless bioprosthesis for repair of acute type A aortic dissection.

METHODS

Between May 2005 and December 2009, 24 of 80 patients underwent root replacement using the Medtronic Freestyle xenograft (Medtronic Inc, Minneapolis, Minn) at the Meijer Heart Center. Prospective data collection was used for retrospective review. Univariate comparisons of preoperative, intraoperative, and postoperative variables were performed between patients who underwent stentless root bioprosthesis for the correction of acute type A aortic dissection (n = 24).

RESULTS

The mean age of patients was 57 years, with 15 patients aged less than 65 years. Axillary and femoral artery cannulation were used in 16 patients (67%) and 7 patients (29%), respectively. Median crossclamp and cardiopulmonary bypass times were 198 minutes (92-480 minutes) and 288 minutes (109-588 minutes), respectively. Median circulatory arrest time was 28 minutes (24-50 minutes). Operative mortality rate was 25%. Actuarial 5-year survival was 62.5%. No patients required redo aortic root replacement.

CONCLUSIONS

Stentless valve implantation can be accomplished with satisfactory early and midterm clinical outcomes and is a valuable option in patients with acute aortic dissection who require root replacement.

摘要

目的

无支架异种移植物具有优越的血液动力学和出色的长期临床性能,这已得到充分描述。然而,无支架瓣膜在急性 A 型夹层患者中的早期和中期临床结果尚不清楚。本研究评估了无支架生物瓣修复急性 A 型主动脉夹层的早期和中期临床结果。

方法

2005 年 5 月至 2009 年 12 月,80 例患者中有 24 例在 Meijer 心脏中心接受了 Medtronic Freestyle 异种移植物(美敦力公司,明尼苏达州明尼阿波利斯市)的根部置换。使用前瞻性数据收集进行回顾性审查。对接受无支架根部生物瓣治疗急性 A 型主动脉夹层的患者(n=24)的术前、术中、术后变量进行单变量比较。

结果

患者的平均年龄为 57 岁,其中 15 例年龄小于 65 岁。16 例(67%)和 7 例(29%)患者分别使用腋动脉和股动脉插管。中位体外循环和升主动脉阻断时间分别为 198 分钟(92-480 分钟)和 288 分钟(109-588 分钟)。中位停循环时间为 28 分钟(24-50 分钟)。手术死亡率为 25%。5 年生存率为 62.5%。无患者需要再次行主动脉根部置换术。

结论

无支架瓣膜植入术可获得满意的早期和中期临床结果,是需要根部置换的急性主动脉夹层患者的一种有价值的选择。

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