[跨膜蛋白16A（TMEM16A）在胃癌中的表达及其临床意义]
[Expression of TMEM16A in gastric carcinoma and its clinical implications].
作者信息
Yang Jun, Liu Ni, Kang Anjing, Jin Yaofeng, Wang Junning, Su Baoshan, Chen Xiaoli, Li Zongfang
机构信息
Department of Pathology, Second Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(6):794-7.
OBJECTIVE
To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications.
METHODS
A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.
RESULTS
TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).
CONCLUSION
Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.
目的
探讨跨膜蛋白16A（TMEM16A）在胃癌中的表达及其临床意义。
方法
收集72例胃癌手术标本，采用免疫组织化学染色检测TMEM16A的表达。
结果
在肿瘤细胞的细胞质和细胞膜中检测到TMEM16A表达。在72例肿瘤组织标本中，TMEM16A表达的总阳性率为80.56%（58/72），显著高于癌旁组织（4.17%，3/72，P<0.005）。
结论
大多数胃癌病例中存在TMEM16A的异常表达。TMEM16A可作为胃癌诊断和治疗的新候选靶点。
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