Endocrine Research unit, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark, 2400 NV Copenhagen.
J Diabetes Complications. 2012 Sep-Oct;26(5):430-4. doi: 10.1016/j.jdiacomp.2012.05.006. Epub 2012 Jun 12.
Recent literature on acute diabetic Charcot osteoarthropathy (CA) reports unusually long periods of off-loading. Data suggest that this might increase the re-currence rate. Subsequently we evaluated the influence of duration of off-loading on the risk of required re-casting.
In this retrospective consecutive series from 2000 to 2005, 56 people with diabetes and an acute Charcot foot were included. The inclusion criteria were an initial persistent temperature difference more than 2°C between the two feet, oedema, and typical hot spots on a bone scintigram, radiology, and a typical clinical course. Treatment was off-loading in a removable cast and 2 crutches. In-door walking was allowed. Gradually augmented weight bearing was prescribed when the skin temperature difference had decreased to a level less than 2°C and edema had subsided. Re-casting was required for immediate exacerbation during re-load as well as for recurrence - defined as new swelling and skin temperature difference of more than 2°C in the same foot occurring after a stable interval of at least one month after full weight bearing.
The duration of off-loading for all patients was 141±21 days (mean±SD). Three patients (5%) were re-casted immediately for exacerbation after re-load and 7 patients (12 %) after recurrence of the CA. Duration of re-casting was 79±44 days. The primary period of off-loading was not statistically significantly different for those not requiring versus those requiring re-casting: 142±24 days compared to 134±41 days. Neither were the differences in demographic data, metabolic regulation, BMI or localization of CA.
Patients with risk of exacerbation or recurrence of CA could not be identified in the present study and there was no relation to the duration of off-loading. Nevertheless off-loading periods with immobilisation should be kept as short as possible, due to other side effects. This can be obtained by early gradual augmented re-loading.
近期有关急性糖尿病性夏科氏关节病(CA)的文献报道称,患者需要长时间的免荷。有数据表明,这可能会增加复发的风险。因此,我们评估了免荷时间对再次打石膏固定需求的影响。
在这项回顾性连续研究中,纳入了 2000 年至 2005 年间的 56 名糖尿病合并急性夏科氏足患者。纳入标准为:双侧足部初始温差持续>2°C,存在水肿,骨闪烁扫描、影像学检查存在典型热点,且具有典型的临床病程。治疗采用可移动石膏和 2 副拐杖进行免荷。室内允许步行。当皮肤温差降至<2°C且水肿消退时,逐渐增加负重。在再次负重时出现明显加重以及在完全负重后至少 1 个月的稳定期后出现同一足部的新肿胀和皮肤温差>2°C的情况下,需要再次打石膏固定。
所有患者的免荷时间为 141±21 天(均值±标准差)。有 3 名患者(5%)在再次负重后出现加重而立即再次打石膏固定,有 7 名患者(12%)在 CA 复发后再次打石膏固定。再次打石膏固定的时间为 79±44 天。无需再次打石膏固定和需要再次打石膏固定的患者的首次免荷时间无统计学差异:142±24 天比 134±41 天。两组患者的人口统计学数据、代谢控制、BMI 或 CA 的定位也无差异。
在本研究中,未能确定有加重或复发 CA 风险的患者,且与免荷时间也无关。尽管如此,由于其他副作用,固定的免荷期应尽可能保持较短。这可以通过早期逐渐增加负重来实现。