Department of Orthopaedics, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, China.
J Biomed Mater Res A. 2012 Nov;100(11):2991-3000. doi: 10.1002/jbm.a.34228. Epub 2012 Jun 15.
The aim of our study was to construct macroporous calcium phosphate bone cements (CPCs) with enhanced osteogenic potential. For this purpose, 300 mM sodium dodecyl sulfate (SDS) as an air-entraining agent was added to the liquid phase and 1, 5, and 10% simvastatin (SIM) was homogenized with the solid phase. The physical and mechanical characteristics of the test samples were investigated. Biological properties of the new CPCs were examined after intramuscular and endosteal implantation in rabbits. The introduction of SDS produced interconnected macropores and did not significantly affect initial setting time, transformation of solid phase to hydroxyapatite, and biocompatibility of CPCs. Large amounts (10 wt %) of SIM could decrease the compressive strength and induce severe muscular necrosis and inflammatory reaction. Small amounts (1 wt %) of SIM were compatible with the CPCs did not affect the physico-chemical properties or biocompatibility and were sufficient to enhance the osteogenic potential of macroporous CPCs.
我们研究的目的是构建具有增强成骨潜力的大孔磷酸钙骨水泥（CPC）。为此，在液相中加入 300mM 十二烷基硫酸钠（SDS）作为加气剂，并用固相均匀混合 1%、5%和 10%辛伐他汀（SIM）。研究了测试样品的物理和机械特性。在兔肌内和骨内植入后，研究了新型 CPC 的生物学特性。SDS 的引入产生了相互连通的大孔，不会显著影响初始凝固时间、固相向羟基磷灰石的转化以及 CPC 的生物相容性。大量（10wt%）SIM 会降低抗压强度并引起严重的肌肉坏死和炎症反应。少量（1wt%）SIM 与 CPC 相容，不会影响物理化学性质或生物相容性，足以增强大孔 CPC 的成骨潜力。
